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Video: When and How Does Fertility Decline?

Dr. Eric Flisser, a New York fertility doctor with Reproductive Medicine Associates (RMA) of New York, explains how egg quality, egg quantity, and age affect a woman's fertility.

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0:00:00.000,0:00:05.000 (text on screen): Ask the Expert 0:00:05.000,0:00:07.000 Fertility Authority. Your Most Trusted Source 0:00:07.000,0:00:12.000 When and how does fertility decline? 0:00:12.000,0:00:18.000 Eric Flisser, M.D., Reproductive Medicine Associates of New York: So, it's a difficult reality that human reproduction is limited. 0:00:18.000,0:00:25.000 And, primarily, it's limited because the number of eggs that a woman has is a finite resource. 0:00:25.000,0:00:30.000 And even since before she was born, a woman is losing her eggs. 0:00:30.000,0:00:33.000 At the peak, a woman has about five to six million eggs. 0:00:33.000,0:00:37.000 By the time she's born, there are about two to three million left. 0:00:37.000,0:00:42.000 And then by the time she reaches puberty, even before she's ovulated even a single egg, there are only about 500,000 left. 0:00:42.000,0:00:48.000 So, about 90 percent of all of the eggs that a woman starts with are gone by the time she reaches puberty. 0:00:48.000,0:00:54.000 And with only one exception that I can think of, there's really no way to stop that loss of eggs. 0:00:54.000,0:01:00.000 Whether a woman is pregnant or she's on the birth control pill, that process is basically unstoppable. 0:01:00.000,0:01:05.000 And as the number of eggs dwindles, the quality of those eggs gets worse as well. 0:01:05.000,0:01:10.000 So, not only are there fewer remaining, but they don't work as well as they had when a woman was younger. 0:01:10.000,0:01:17.000 And that is, primarily, the major obstacle to fertility when there are no other medical problems. 0:01:17.000,0:01:22.000 Female fertility certainly reaches its peak somewhere in the, probably, late teens and twenties, 0:01:22.000,0:01:30.000 and then begins to take a significant decline in the mid-30s, and certainly by 37, 38 an even more significant decline. 0:01:30.000,0:01:36.000 And it's basically impossible for us to predict who will get pregnant or when they will get pregnant. 0:01:36.000,0:01:43.000 We can only observe the population at large and see that as women get older, fewer and fewer are getting pregnant at any given time. 0:01:43.000,0:01:51.000 If, after 12 months of trying, in a woman who's younger than 35, or after six months of trying in a woman who's over 35, 0:01:51.000,0:01:58.000 conception has not occurred, that would be an appropriate time to see a reproductive endocrinologist for a full fertility evaluation. 0:01:58.000,0:02:02.000 (text on screen): Ask the Expert 0:02:02.000,0:02:03.000 Fertility Authority. Your Most Trusted Source

Video: What is PGD for Gender Selection?

PGD, or preimplantation genetic diagnosis screens embryos and allows your fertility doctor to replace one healthy embryo of the sex you desire. Dr. Daniel Potter of HRC Fertility explains.

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0:00:00.000,0:00:03.000 (text on screen): Fertility Authority. Your Most Trusted Source 0:00:03.000,0:00:05.000 Ask the Experts 0:00:05.000,0:00:10.000 What is PGD for Gender Selection? 0:00:10.000,0:00:14.000 Dr. Daniel Potter, HRC Fertility: The primary method of gender selection is in vitro fertilization 0:00:14.000,0:00:18.000 with pre-implantation genetic screening of the embryos. 0:00:18.000,0:00:26.000 And when we do this, we can check the embryos for all 24 chromosomes and also know the gender of the embryo, 0:00:26.000,0:00:34.000 and we can select just a single embryo of the desired gender, and place that embryo back, and have a very high pregnancy rate. 0:00:34.000,0:00:44.000 So, you know, when we look at all 24 chromosomes with the PGD, we can tell for sure that the embryo is normal or not, 0:00:44.000,0:00:48.000 and it turns out that when in vitro fertilization doesn't work, one of the primary reasons it doesn't work 0:00:48.000,0:00:52.000 is because the embryos that are being transferred are not normal. 0:00:52.000,0:00:56.000 So, knowing that they're normal is very helpful. 0:00:56.000,0:01:02.000 There are other PGD techniques, FISH being the chief among them, where you can look at the X and the Y chromosome, 0:01:02.000,0:01:05.000 and they are very accurate for selecting gender. 0:01:05.000,0:01:11.000 However, they do not do any good at all in terms of embryo screening. 0:01:11.000,0:01:17.000 If we use the 24-chromosome technology, we can put back, you know, as I said, a single embryo. 0:01:17.000,0:01:26.000 The gender, you know, specificity with that technique in our hands has been 100 percent. 0:01:26.000,0:01:32.000 So, what we do with this technology is we give the female medicine so that she makes multiple eggs 0:01:32.000,0:01:36.000 rather than the single egg that she makes in a normal cycle. 0:01:36.000,0:01:43.000 And then we remove those eggs, and that's done through the vagina using a needle guided by ultrasound. 0:01:43.000,0:01:48.000 The patient's asleep for this, so they don't feel anything or remember anything. 0:01:48.000,0:01:53.000 Once we have the eggs out, we take them to the laboratory and we fertilize them with sperm, 0:01:53.000,0:01:58.000 and at that point the fertilized eggs are; you know, we call them embryos. 0:01:58.000,0:02:01.000 Technically, they're actually pre-embryos. But we call them embryos. 0:02:01.000,0:02:07.000 And so they start off at a single cell and they will divide to the eight-cell stage, 0:02:07.000,0:02:14.000 and at that point we can remove one of the cells and, you know, using various technologies, 0:02:14.000,0:02:21.000 analyze the cell to determine what the chromosomal content is of that cell and then, you know, 0:02:21.000,0:02:26.000 use that information to transfer just the embryos that are healthy and that are normal. 0:02:26.000,0:02:28.000 (text on screen): Fertility Authority. Your Most Trusted Source
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Video: Can High FSH Be Lowered?

FSH levels vary throughout the menstrual cycle. A high FSH level on day 3 of the cycle can empower you and your fertility doctor with information, and help guide a treatment plan. Dr. Pavna Brahma, an Atlanta fertility doctor with Reproductive Biology Associates, explains.

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0:00:00.000,0:00:02.000 (Text on screen): Fertility Authority: Your Most Trusted Source 0:00:02.000,0:00:05.000 Ask the Experts 0:00:05.000,0:00:10.000 Can high FSH be lowered? 0:00:10.000,0:00:13.000 Dr. Pavna Brahma, Reproductive Biology Associates: FSH is a hormone that varies with the menstrual cycle, 0:00:13.000,0:00:22.000 so it's important, when you get it clinically, to get the test early in the follicular phase, right after the period has begun. 0:00:22.000,0:00:26.000 Although we don't necessarily have treatments to decrease one's FSH level, 0:00:26.000,0:00:34.000 having an elevated FSH kind of empowers us with that knowledge to know how quickly we should move into fertility treatments 0:00:34.000,0:00:39.000 and how to choose different dosing protocols and drug levels that might be needed. 0:00:39.000,0:00:43.000 But we don't really have a lot of clinical ways to lower one's FSH, 0:00:43.000,0:00:50.000 because that typically would mean that we would have a way to increase one's egg reserve, and science isn't quite there. 0:00:50.000,0:00:52.000 (Text on screen): Fertility Authority: Your Most Trusted Source
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Video: Is PCOS Hereditary?

PCOS appears to be hereditary, according to Dr. Keri Greenseid, a fertility doctor with IRMS at St. Barnabas.

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0:00:00.000,0:00:03.000 (text on screen): Fertility Authority. Your Most Trusted Source 0:00:03.000,0:00:05.000 Ask the Experts 0:00:05.000,0:00:10.000 Is PCOS herediatry? 0:00:10.000,0:00:11.000 Dr. Keri Greenseid, The Institute of Reproductive Medicine and Science at St. Barnabas Medical Center: PCOS is multifactorial, 0:00:11.000,0:00:17.000 meaning that there are many different causes of it, and we don't know a specific gene that causes PCOS. 0:00:17.000,0:00:23.000 But we do know that it is hereditary, and it can be more common in patients who have other family members 0:00:23.000,0:00:25.000 or a mother with PCOS. 0:00:25.000,0:00:28.000 (text on screen): Fertility Authority. Your Most Trusted Source
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Video: How Are Fibroids Diagnosed and Treated?

Dr. Jenna McCarthy, a fertility doctor with South Florida Institute of Reproductive Medicine, explains what fibroids are and how they are diagnosed and treated.

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0:00:00.000,0:00:03.000 (text on screen): Fertility Authority. Your Most Trusted Source 0:00:03.000,0:00:05.000 Ask the Experts 0:00:05.000,0:00:10.000 How are fibroids diagnosed and treated? 0:00:10.000,0:00:14.000 Dr. Jenna McCarthy, South Florida Institute for Reproductive Medicine: Most of the time, fibroids are initially diagnosed on ultrasound. 0:00:14.000,0:00:23.000 And then they can be definitively diagnosed from a fertility standpoint by either a saline infusion sonogram, or an HSG. 0:00:23.000,0:00:28.000 If the fibroid is well away from the cavity, and it's not changing the shape of the cavity at all, 0:00:28.000,0:00:32.000 and it's not causing you any other symptoms, there's no reason you need to have it taken out. 0:00:32.000,0:00:37.000 So, doctors typically will recommend that you have the fibroid taken out if it's changing the shape of the cavity, 0:00:37.000,0:00:41.000 or if it's causing some of the other symptoms. 0:00:41.000,0:00:43.000 Fibroids are typically removed one of two ways. 0:00:43.000,0:00:47.000 You can either have them removed by having a surgery, either laparoscopically 0:00:47.000,0:00:52.000 or an open surgery where they make an incision in the belly, and have the fibroids removed. 0:00:52.000,0:00:57.000 Alternatively, fibroids that are completely within the cavity can sometimes be removed vaginally. 0:00:57.000,0:01:03.000 It depends on where the fibroid is. So, let's start with a large fibroid that's large enough that it's changing the shape of the cavity. 0:01:03.000,0:01:10.000 That type of fibroid might be removed laparoscopically, which is a couple of small incisions on the belly, nothing big. 0:01:10.000,0:01:15.000 The procedure is usually performed as an outpatient procedure, which means that you can go home the same day, 0:01:15.000,0:01:20.000 sleep in your own bed, take your pain medicines yourself, instead of having to be in the hospital. 0:01:20.000,0:01:26.000 The healing time from that is typically two to six weeks, depending on the woman and how active she is. 0:01:26.000,0:01:30.000 And then we usually ask you to wait three months before trying to get pregnant. 0:01:30.000,0:01:35.000 Some doctors will err on the side of caution and say as much as six months before trying to get pregnant. 0:01:35.000,0:01:41.000 And then, typically, if the fibroid that was removed was large enough that we actually went all the way through the wall 0:01:41.000,0:01:45.000 of the uterus to take it out, we'll recommend a c-section for delivery, 0:01:45.000,0:01:51.000 to help prevent the chance that the scar that's left in its place doesn't pop open during labor. 0:01:51.000,0:01:57.000 The other way to remove fibroids is hysteroscopically, or vaginally. Those are fibroids that are completely within the cavity. 0:01:57.000,0:02:02.000 So, basically, they can put a little camera inside the uterus and look around; you can see the whole fibroid. 0:02:02.000,0:02:08.000 Those, the recovery time is even faster. The surgery itself, again, is outpatient. You go home the same day. 0:02:08.000,0:02:11.000 The pain is much, much less associated with it. 0:02:11.000,0:02:15.000 Most women are back to work within a week to two weeks. Some women don't even need that much time. 0:02:15.000,0:02:19.000 And we usually don't ask you to wait more than one normal period before you try and get pregnant. 0:02:19.000,0:02:26.000 And neither of the two surgeries make it so that you can or cannot have fertility treatments. 0:02:26.000,0:02:29.000 Some gynecologists are extremely skilled at removing fibroids. 0:02:29.000,0:02:37.000 Other gynecologists prefer to refer those patients to either a reproductive endocrinologist or a minimally invasive surgeon. 0:02:37.000,0:02:45.000 The advantage to doing that is most REs and minimally invasive surgeons are trained in doing laparoscopic myomectomies. 0:02:45.000,0:02:50.000 The difference between a laparoscopic myomectomy and an abdominal myomectomy is the recovery time. 0:02:50.000,0:02:55.000 With a laparoscopic, most women, really, are up and around and doing for themselves in about two weeks. 0:02:55.000,0:03:00.000 It may be six weeks before they feel 100 percent, but they're usually at 80 percent or better by two weeks. 0:03:00.000,0:03:05.000 With an abdominal myomectomy, you've actually gone through the big muscles of the abdominal wall, 0:03:05.000,0:03:12.000 so, just like a c-section or any other major abdominal surgery, it takes you that full six to eight weeks to feel like yourself again. 0:03:12.000,0:03:14.000 (text on screen): Fertility Authority. Your Most Trusted Source
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Video: What Lifestyle Factors Affect Fertility?

According to Dr. David Keefe, a New York fertility doctor at NYU Fertility Center, there are a number of lifestyle factors that affect fertility and egg quality including smoking, weight, certain drugs and genetic problems

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0:00:00.000,0:00:05.000 (text on screen): Ask the Expert 0:00:05.000,0:00:07.000 Fertility Authority. Your Most Trusted Source 0:00:07.000,0:00:12.000 What lifestyle factors affect fertility? 0:00:12.000,0:00:18.000 David L. Keefe, M.D., NYU Fertility Center: While we don't completely understand all the factors that determine egg quality, 0:00:18.000,0:00:25.000 there are a number of lifestyle factors that are known to be associated with poor egg quality. 0:00:25.000,0:00:32.000 For example, women that smoke, particularly women that smoke early on in their lives, continue to smoke, and smoke heavily 0:00:32.000,0:00:35.000 have lower egg quality. 0:00:35.000,0:00:37.000 They tend to go through menopause a little earlier. 0:00:37.000,0:00:43.000 They have lower fertility when they go through any given treatment than women who didn't smoke. 0:00:43.000,0:00:47.000 There are some genetic conditions that cause early deterioration of eggs. 0:00:47.000,0:00:59.000 Women that are carriers of a premutation in the Fragile X mutation are predisposed to early menopause and disrupted egg quality. 0:00:59.000,0:01:08.000 Some women who are too overweight or too underweight may have subtle abnormalities in egg quality. 0:01:08.000,0:01:13.000 So, the secret to maintaining healthy egg quality is to avoid smoking. 0:01:13.000,0:01:19.000 Whenever possible, avoid drugs that can disrupt egg quality. 0:01:19.000,0:01:26.000 And, of course, if you carry genetic problems, have those tested before you attempt to conceive, 0:01:26.000,0:01:32.000 such as Fragile X or other genetic problems that are predisposed to early menopause. 0:01:32.000,0:01:36.000 (text on screen): Ask the Expert 0:01:36.000,0:01:37.000 Fertility Authority. Your Most Trusted Source
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Video: Can Women Improve Their Fertility As They Age?

While "40 may be the new 30" in some instances, it doesn't pertain to your fertility. Dr. Kimberly Thompson, with South Florida Institute of Reproductive Medicine explains.

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0:00:00.000,0:00:03.000 (text on screen): Fertility Authority. Your Most Trusted Source 0:00:03.000,0:00:05.000 Ask the Experts 0:00:05.000,0:00:10.000 Can women improve their fertility as they age? 0:00:10.000,0:00:13.000 Dr. Kimberly Thompson, South Florida Institute for Reproductive Medicine: Many times nowadays, women think 0:00:13.000,0:00:22.000 because they are healthy and active, exercising and taking their vitamins, that that means they're going to be more fertile. 0:00:22.000,0:00:28.000 And the reality is that, yes, if they don't smoke, that will improve their chances of being able to get pregnant, 0:00:28.000,0:00:32.000 because smoking does diminish our egg supply. 0:00:32.000,0:00:40.000 But as far as we can tell, there is nothing about these other healthy lifestyle choices that truly saves the number of eggs that we have. 0:00:40.000,0:00:46.000 We hear a lot nowadays about "40 being the new 30," and these sorts of things, 0:00:46.000,0:00:52.000 but it's been studied and there doesn't seem to be a real difference. 0:00:52.000,0:00:55.000 The main thing we can do, as I said, is not smoking. 0:00:55.000,0:01:02.000 But otherwise, being healthy in other ways may help a woman get through pregnancy healthy 0:01:02.000,0:01:09.000 (not develop gestational diabetes or high blood pressure), so I don't mean to knock being in good health. That's still important. 0:01:09.000,0:01:14.000 But it doesn't seem to protect the actual eggs from what we can tell. 0:01:14.000,0:01:17.000 (text on screen): Fertility Authority. Your Most Trusted Source
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Video — Ask the Expert: How Does Age Impact Fertility?

New York fertility doctor John Zhang, Founder and Director of New Hope Fertility Center in New York, discusses the relationship between age and fertility. After the age of 35, a woman's fertility declines each year. At the age of 40, your chance of getting pregnant is approximately 20 percent with the most aggressive fertility treatment protocol.

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Video: How Does a Surrogate Get Pregnant?

What is the process that a surrogate goes through to get pregnant? Dr. Melissa Yih, with IVF New Jersey, explains.

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0:00:00.000,0:00:03.000 (text on screen): Fertility Authority. Your Most Trusted Source 0:00:03.000,0:00:05.000 Ask the Experts 0:00:05.000,0:00:10.000 How does a surrogate get pregnant? 0:00:10.000,0:00:17.000 Dr. Melissa Yih, IVF New Jersey: The cycle, basically, involves the surrogate being on medication to synchronize her cycle 0:00:17.000,0:00:25.000 with either the intended parent, if the intended parent is planning on donating her eggs to be used to create the embryos, 0:00:25.000,0:00:32.000 or, in certain cases, also, an egg donor might be used to provide her eggs for the cycle. 0:00:32.000,0:00:41.000 So, the surrogate would be placed on birth control pills initially to synchronize her cycle with whomever is donating the eggs. 0:00:41.000,0:00:47.000 She is then placed on a medication called Lupron, which is used to suppress her natural cycle. 0:00:47.000,0:00:53.000 And then we start her on estrogen to mimic the first half of a normal menstrual cycle. 0:00:53.000,0:01:01.000 And then once the egg donor or intended parent is being scheduled for retrieval, then we put her on progesterone, 0:01:01.000,0:01:07.000 which is a medication or hormone that's required for the second half of a normal woman's menstrual cycle. 0:01:07.000,0:01:11.000 And that hormone would be used to help support the pregnancy. 0:01:11.000,0:01:18.000 At that point, when the either egg donor or intended parent is ready for retrieval, we retrieve the eggs, 0:01:18.000,0:01:25.000 we fertilize the sperm, and then the embryo is transferred either three or five days later back to the surrogate. 0:01:25.000,0:01:33.000 And the transfer itself is a fairly simple procedure. It doesn't require any anesthesia. 0:01:33.000,0:01:41.000 It typically is done within a minute or two, and it doesn't require that the surrogate stays in the hospital or stays in the clinic 0:01:41.000,0:01:44.000 for a prolonged period of time. She can go home after the procedure. 0:01:44.000,0:01:50.000 The pregnancy test for the surrogate is typically done about two weeks after the retrieval, 0:01:50.000,0:01:56.000 and at that point if she is pregnant then she continues on the estrogen and progesterone support 0:01:56.000,0:02:02.000 until we can see evidence that the placenta is starting to make hormones to support the pregnancy. 0:02:02.000,0:02:08.000 If she's not pregnant, then she stops the medication and that's the end of the cycle. 0:02:08.000,0:02:11.000 (text on screen): Fertility Authority. Your Most Trusted Source

Video: What Is the Benefit of IVF with Single Embryo Transfer?

Single embryo transfer — putting back one embryo in an IVF cycle — is often the safest and healthiest option for the mother and the baby, explains Dr. Natalie Cekleniak, a fertility doctor with IRMS at St. Barnabas.

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0:00:00.000,0:00:03.000 (text on screen): Fertility Authority. Your Most Trusted Source 0:00:03.000,0:00:05.000 Ask the Experts 0:00:05.000,0:00:10.000 What is the benefit of single embryo transfer with IVF? 0:00:10.000,0:00:12.000 Dr. Natalie Cekleniak, The Institute of Reproductive Medicine at St. Barnabas Medical Center: SET, or single embryo transfer, 0:00:12.000,0:00:19.000 refers to our ability now, which is really exciting for us to consider transferring just one embryo 0:00:19.000,0:00:23.000 at the time of an IVF cycle and the time of embryo transfer. 0:00:23.000,0:00:29.000 Most people know that many patients require more than one embryo to be transferred 0:00:29.000,0:00:34.000 in order to achieve the pregnancy rates that we all desire, and that's been going on for quite a long time. 0:00:34.000,0:00:39.000 But, fortunately, as the field has progressed and as implantation rates have improved, 0:00:39.000,0:00:45.000 we can now consider transferring just one embryo and still achieve really exciting pregnancy rates. 0:00:45.000,0:00:50.000 This, of course, has the benefit of reducing the multiple gestation rate dramatically. 0:00:50.000,0:00:53.000 So, it's really an exciting time for our field. 0:00:53.000,0:00:58.000 Well, we're really excited about single embryo transfer because we've waited for this. 0:00:58.000,0:01:06.000 I mean, our field has worked so hard to improve culture systems and ways to improve embryo implantation rates 0:01:06.000,0:01:11.000 so we could get to this point of being able to offer single embryo transfer to a large group of patients. 0:01:11.000,0:01:15.000 It's a little bit hard for patients to always understand why that's such a good thing. 0:01:15.000,0:01:24.000 Because, of course, they're so eager to be pregnant, and they know that the more embryos that are transferred results in higher pregnancy rates in general. 0:01:24.000,0:01:30.000 And, of course, in their situation, they want to do everything they can to get the best pregnancy rate. 0:01:30.000,0:01:35.000 And twins are often just, you know, such a wonderful event. 0:01:35.000,0:01:42.000 Patients feel doubly lucky in many cases, so twins can be, you know, just a fantastic outcome. 0:01:42.000,0:01:49.000 I think the patients need to just realize and be educated that twins do present so many increased complications, you know. 0:01:49.000,0:01:56.000 And it's not that we wouldn't be happy about healthy, viable twins at term. We love that. And fortunately we see that a lot. 0:01:56.000,0:01:59.000 But we also see the twins who are born early. 0:01:59.000,0:02:05.000 You know, there is a ten-fold increase rate of preterm birth with twins, and that, of course, 0:02:05.000,0:02:14.000 includes all the complications of early delivery, and being born at early gestational ages, the complications that come along with that. 0:02:14.000,0:02:20.000 So while we're really excited about this, I think patients need to understand that reducing the multiple rate 0:02:20.000,0:02:27.000 really is critical for them to have a healthy, uncomplicated, smooth, full-term birth. That's the goal. 0:02:27.000,0:02:33.000 And it's hard to; you know, they need to manage that with their expectations of 0:02:33.000,0:02:37.000 "just give me the best pregnancy rate and we would love twins." 0:02:37.000,0:02:47.000 Full-term twins we love, too, but they really need to understand that they see all the twins out there in school and in the playground and, 0:02:47.000,0:02:49.000 you know, those twins are healthy and doing well. 0:02:49.000,0:02:54.000 But not everybody sees the twins that deliver early and are in the NICU struggling and don't always get there. 0:02:54.000,0:03:00.000 And we want to make sure they really understand the risks that they take on if they decline a single embryo transfer 0:03:00.000,0:03:03.000 and they do have two replaced instead. 0:03:03.000,0:03:05.000 (text on screen): Fertility Authority. Your Most Trusted Source
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