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Reproductive Endocrinologists Answer Your Questions

Video — Journey to the Crib Episode 8: Polycystic Ovarian Syndrome (PCOS)

Source: East Coast Fertility
Dr. David Kreiner, a fertility doctor and founder of East Coast Fertility, and Pamela Madsen, Fertility Advocate, discuss polycystic ovarian syndrome (PCOS) which is often diagnosed when a woman does not ovulate, has irregular periods, or infertility.

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[text on screen]: Journey to the Crib. Fertility Talk with Pam and Dr. Dave Pamela Madsen: Hi. I'm Pamela Madsen, and welcome to another segment of Journey to the Crib. And I'm here with Dr. Dave Kreiner, who is the founder of East Coast Fertility. Thanks for joining us! [text on screen]: Episode 8: Polycystic Ovarian Syndrome (PCOS) Pamela Madsen: Can you talk a little bit about PCOS and what it means to fertility? Dr. Dave Kreiner: PCOS is characterized by having these numerous, small follicles that can be seen by ultrasound. And in fact, we make the diagnosis based on that ultrasound picture in the presence of either failure to ovulate, irregular menses, or infertility. Pamela Madsen: And some PCOS people have weight issues. Dr. Dave Kreiner: PCOS is caused by a glucose intolerance that will accentuate a woman's response to carbohydrates. Their insulin goes up in response to a carbohydrate meal much higher than normal. This insulin then stimulates a woman's ovaries to produce testosterone. The testosterone, on the other hand, will prevent a woman's ovary from ovulating; prevent regular ovulation and menses and cause infertility. The testosterone can also cause a woman to have increased facial and body hair. It can cause thinning of a woman's hair on her scalp. And it can increase the lipids in her blood. So you mentioned cardio problems can lead to hypertension. And even more than that, the high glucose can lead to diabetes in some cases. Pamela Madsen: So I imagine that it's really important for women, whether they're trying to conceive or not trying to conceive, to really get a hold of this disorder. Dr. Dave Kreiner: What we like to do is treat with a diabetes drug called Metformin or Glucophage, which improves their glucose tolerance, decreasing the insulin levels, decreasing the testosterone levels. This goes a long way in decreasing the patient's symptoms. But at the same time it's important for them to change their diet, control and limit the carbohydrate intake at any meal, increase their exercise so that they improve their glucose tolerance. Pamela Madsen: So, if I'm a woman with PCOS, am I going to have a more difficult time doing fertility treatments like in vitro fertilization? You know; how do I stack up? Dr. Dave Kreiner: What a PCOS patient has that many of our other patients don’t have is number of eggs. So, a PCOS patient has so many follicles that we worry more about hyperstimulation than we do failure to recruit sufficient eggs to get high-quality embryos. Pamela Madsen: OK, so, if I'm a woman with PCOS and I've got to deal with acne and I've got to deal with not eating cupcakes and exercising, the good news is that I'm really treatable if I want to have a baby. Dr. Dave Kreiner: Absolutely. Pamela Madsen: Love that! OK. If I've gotta give up the cupcakes. [text on screen] To Learn More Visit: www.thefertilitydoc.com www.thefertilityadvocate.com For a Free Fertility Consultation Visit: www.eastcoastfertility.com

Video — Journey to the Crib Episode 7: Financing Fertility Treatment

Source: East Coast Fertility
In this episode of Journey to the Crib, Dr. David Kreiner, a fertility doctor and Founder of East Coast Fertility, and Pamela Madsen, Fertility Advocate, discuss what programs East Coast Fertility has in place to help infertility patients finance fertility treatment.

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[text on screen]: Journey to the Crib. Fertility Talk with Pam and Dr. Dave Pamela Madsen: Hi. I'm Pamela Madsen, and welcome to another segment of Journey to the Crib. And I'm here with Dr. Dave Kreiner, who is the founder of East Coast Fertility. Thanks for joining us! [text on screen]: Episode 7: Financing Treatment Pamela Madsen: With the recession and the cutback in credit for people, a lot of the traditional ways that couples who were trying to have babies financed their treatment was through, you know, second mortgages on their home, credit, Mom and Dad, retirement funds. A lot of these things are shrinking now and they're not available. So, what are programs like East Coast Fertility doing to help patients finance their fertility treatments? Dr. Dave Kreiner: Fortunately, we were selected by the New York State Department of Health to provide the grants for IVF. We also provide our own, internal East Coast Fertility grants. And we have IVF studies as well. The New York State department of health grant is especially rich. Unfortunately, there is limited funding so we can't offer it to everybody. But basically they're income-based. Our internal grants, we can offer IVF for couples that have an income of $100,000 or less. The basic IVF at $6,900, and, again, it's adjusted by income up to $200,000. The cost share for patients for basic IVF is $9,900. We also have some financing for those patients who don't have the cash up front. Fortunately, they've been able to utilize our financing program, which seems to be quite fair. We also have, as we mentioned, the IVF studies. So, patients who do the ECF grant, as we call it, are able to get their medications covered and even more grant money when they do the IVF study in addition to receiving the ECF grant. Pamela Madsen: You know, I was once debating somebody on health care on television and he said to me, "You know, if a patient can't afford $60,000, you know, to have their children, then they shouldn't be parents." And I looked at this guy and I said, "Did your mother have $60,000 in a savings account when she conceived you?" And the guy turned about five shades of red and he said, "No, she didn't." So, I think that's, you know, I think that's a really good lesson. [text on screen] To Learn More Visit: www.thefertilitydoc.com www.thefertilityadvocate.com For a Free Fertility Consultation Visit: www.eastcoastfertility.com

Video — Journey to the Crib Episode 6: High FSH & Your Biological Clock

Source: East Coast Fertility
Dr. David Kreiner, a fertility doctor and founder of East Coast Fertility, and Pamela Madsen, Fertility Advocate, talk about the impact of age and FSH on fertility.

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[text on screen]: Journey to the Crib. Fertility Talk with Pam and Dr. Dave Pamela Madsen: Hi. I'm Pamela Madsen, and welcome to another segment of Journey to the Crib. And I'm here with Dr. Dave Kreiner, who is the founder of East Coast Fertility. Thanks for joining us! [text on screen]: Episode 6: High FSH and Your Biological Clock. Pamela Madsen: You know, patients get diagnosed with FSH. They don't know if it's a high number, a low number, what it means. Can you tell us a little bit? Dr. Dave Kreiner: Yes. Pam, if I had one wish as a doctor in infertility, it would be that my patients or all prospective patients understood the impact of age; the impact of FSH. Unfortunately, though the word has been out, it's not getting down to the patients who still will try on their own for years and years, go to their OB-GYN, and oftentimes not initiate any aggressive fertility treatment even though they're over 35, approaching 40 and sometimes even past age 40. There doesn't seem to be enough of awareness of the effect of age on your fertility. Pamela Madsen: So I go in to the doctor and he says I have high FSH. What is that telling me, as a patient? Dr. Dave Kreiner: The FSH is a pituitary hormone that will respond to your ovaries' production of estradiol and inhibin. And if the number of eggs is decreasing and the number of cells that produce estrogen and inhibin is decreasing, then there's less negative feedback on the pituitary production of FSH, so FSH goes up. Pamela Madsen: A high FSH is really telling them their eggs have aged. You can't, like, fix it, right? Or can you? Dr. Dave Kreiner: Well, Pam, it's not exactly that the eggs have aged. It's that they're running out. There aren't as many. And if you're young and your FSH is going up, well, that's not nearly as bad. Because when you're young it's still likely that most of the eggs are healthy, most of the eggs are genetically normal. And with the help of a reproductive endocrinologist, we can capture those healthy eggs, fertilize them, and hopefully get you pregnant. There's still a pretty good chance. Pamela Madsen: So, a high FSH is not necessarily a death knell for your fertility? Dr. Dave Kreiner: It's never a death knell. Pamela Madsen: It's never a death knell. I like that. So, let's close on this, then. That a high FSH level is not necessarily the end of the game. It doesn't mean, necessarily, that you can't have a baby. Is that true? Dr. Dave Kreiner: That's right. Pamela Madsen: I love that. [text on screen] To Learn More Visit: www.thefertilitydoc.com www.thefertilityadvocate.com For a Free Fertility Consultation Visit: www.eastcoastfertility.com

Video: Journey to the Crib Episode 5: Micro IVF Part II

Source: East Coast Fertility
Dr. David Kreiner, fertility doctor and Founder of East Coast Fertility, and Pamela Madsen, Fertility Advocate, continue their discussion on the benefits of Micro IVF, which uses fewer fertility drugs and is less expensive than standard IVF.

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[text on screen]: Journey to the Crib. Fertility Talk with Pam and Dr. Dave Pamela Madsen: Hi. I'm Pamela Madsen, and welcome to another segment of Journey to the Crib. And I'm here with Dr. Dave Kreiner, who is the founder of East Coast Fertility. Thanks for joining us! [text on screen]: Episode 5: Micro IVF (Part 2) Pamela Madsen: OK, so. There's less drugs in my body. Less injections. The cost is about the same. It has a higher success rate. So why isn't everyone in the United States doing micro IVF right now? Dr. Dave Kreiner: Well, let me just add one other thing. Pamela Madsen: One other thing: OK! Dr. Dave Kreiner: It's also less risky. Pamela Madsen: And it's less risky. OK. Dr. Dave Kreiner: Because your risk of hyperstimulation syndrome from gananotropins IUIs is four times as high as it is with the micro IVF. Your risk of multiple pregnancies is far greater with gonadotropin IUI. It's at least 30 percent chance of having a multiple pregnancy with a 5 percent chance of having triplets or more. Let alone the famous cases of the octomoms. Pamela Madsen: OK, so, I've got to go back to this again. So, as far as I know, there's, like, three doctors in the U.S. doing this. Why? Why isn't everybody offering this to their patients? Do you have an answer? Dr. Dave Kreiner: Well, I think one of the main reasons why this isn't so popular in a lot of programs is it's not the highest pregnancy rate procedure that they can offer. The micro IVF is part of the statistics that is publicized on the Internet. So when a prospective patient is reviewing the success rates of a program, they look at IVF success rates. And micro IVF is included in a program's statistics if the program's success rate is 30 percent from micro IVF. Well, as great as that is compared to insemination, it's less than it is for a full, stimulated traditional IVF. Pamela Madsen: You know, isn't it interesting how the CDC report, the SART report, which is, you know, was created to keep patients safer, sometimes works against us. Because patients are so; you know, doctors are concerned about attracting patients to their program, so they don't do things that would perhaps make them look artificially lower in success rates when that's not true. So it's actually kind of; it's really doing the right thing by patients and perhaps in a roundabout way, not really being shown for that because of the reports. Dr. Dave Kreiner: Well, it fosters a competitiveness because the programs want to look the best in front of their prospective patients. So, what a program might do is choose only to do those patients that have the highest success rates and only do a full, stimulated IVF, which would give those patients the higher success rate. Pamela Madsen: Right. So, if you're an IUI patient, if you're seeing your gynecologist and you've been recommended to do IUI, then you need to find a doctor who can talk to you about micro IVF. Well, thank you, that was really… Dr. Dave Kreiner: It's a much more successful alternative to IUI. Pamela Madsen: Well, thank you. That was really enlightening, and I wish it was around when I was going through this. [text on screen] To Learn More Visit: www.thefertilitydoc.com www.thefertilityadvocate.com For a Free Fertility Consultation Visit: www.eastcoastfertility.com

Video — Journey to the Crib Episode 4: Micro IVF, Part I

Source: East Coast Fertility
Dr. David Kreiner, a fertility doctor and Founder of East Coast Fertility, and Pamela Madsen, Fertility Advocate, discuss Micro IVF. Micro IVF is an alternative to IUI or conventional IVF, where the patient uses clomid then low doses of injectible fertility drugs for two days.

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[text on screen]: Journey to the Crib. Fertility Talk with Pam and Dr. Dave Pamela Madsen: Hi. I'm Pamela Madsen, and welcome to another segment of Journey to the Crib. And I'm here with Dr. Dave Kreiner, who is the founder of East Coast Fertility. Thanks for joining us! [text on screen]: Episode 4: Micro IVF (Part 1) Pamela Madsen: So, one of the things that I find really exciting about your work are the continuation of your development of innovative programs that really serve patients, frankly, as opposed to you. And one of those programs is micro IVF. Can you talk a little bit about it? Dr. Dave Kreiner: Sure. Pam, the micro IVF program; it's offered to all of our patients. But it's ideally suited for the younger patient who either has not even done inseminations yet as an alternative to insemination, or maybe they don't want to do a full stimulation with all the medications that a traditional IVF requires. So what we do with the mini IVF or micro IVF is we treat patients with Clomid, the fertility pills, for five days. Pamela Madsen: They call that the baby aspirin of fertility drugs Dr. Dave Kreiner: That's a good name for it. And then they just take very low-dose injectable hormones for two days following the pills. Pamela Madsen: Just two days; two days of shots? Dr. Dave Kreiner: Two days, and the lowest dose. Pamela Madsen: Wow, where were you when I was going through this? OK. Dr. Dave Kreiner: We monitor them until the eggs are mature. Sometimes it happens in another two days or so. And then we take them to retrieval just as we would with a traditional IVF. We process the sperm, we fertilize the eggs, and we do the ultrasound-guided embryo transfer, just as we would with a traditional IVF. Pamela Madsen: So, what may seem like low-tech to patients, doing IUI, is actually more work or harder on our bodies than doing a mini IVF. Am I getting that right? Dr. Dave Kreiner: It's an interesting perspective that you've raised and that's exactly right. You're taking so much less hormone than you are if you're doing a gonadotropin IUI or insemination cycle. And as you know, the effects that these can have on women is quite significant Pamela Madsen: Oh, I know! My husband used to call to see if it was safe to come home. So, not only am I going to have less fertility drugs in my body, but I'm going to have a higher success rate than if I was doing IUI? Dr. Dave Kreiner: That's the amazing thing about it. Yet the cost is about the same. [text on screen] To Learn More Visit: www.thefertilitydoc.com www.thefertilityadvocate.com For a Free Fertility Consultation Visit: www.eastcoastfertility.com

Video — Journey to the Crib Episode 3: Single Embryo Transfer

Source: East Coast Fertility
Dr. David Kreiner, a fertility doctor and founder of East Coast Fertility, and Pamela Madsen, Fertility Advocate, discuss the advantages of Single Embryo Transfer with IVF.

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[text on screen]: Journey to the Crib. Fertility Talk with Pam and Dr. Dave Pamela Madsen: Hi. I'm Pamela Madsen, and welcome to another segment of Journey to the Crib. And I'm here with Dr. Dave Kreiner, who is the founder of East Coast Fertility. Thanks for joining us! [text on screen]: Episode 3: Single Embryo Transfer. So, what I've noticed by traveling around and listening to all the conferences and having all of our thought leaders in the field pontificating from the podium about the importance of single embryo transfer… And what I've noticed in that conversation is, while they're talking about the importance of single embryo transfer, nobody's really addressing the patient. Because the patient is dealing with the cost of their IVF cycle. If they're going to do a single embryo then they're going to have to create, on purpose, multiple other cycles. Right? Freezing those embryos. Storing those embryos. Then they have the fear of it not working; how are they going to be able to afford those next cycles. And I think what you have created with your single embryo transfer program is unique and it's finally addressing how patients can opt in to doing the right thing by themselves. Can you talk about single embryo transfer program? Dr. Dave Kreiner: The single embryo transfer program is a way for us to take the financial incentive out of the need to put all our eggs in one basket. So, basically, you can go through a single retrieval and transfer, just pay the one IVF cycle fee, and then the freezing of excess embryos is free, storage of the embryos is free. And patients can come back an unlimited number of times for their frozen embryo transfers and it's all covered. Pamela Madsen: So, until they achieve a live birth? Dr. Dave Kreiner: Until they achieve a live birth, yes. Pamela Madsen: Wow. That's really amazing. It's really great. You know, I think we have to be careful. When we're going through infertility we're dealing with a certain kind of pain and we want to fix that pain. We don’t understand the other kinds of pain that could be out there. Such as, you know, children who don't do well because of high multiple birth pregnancy. Losing children because of that. And the financial and emotional stress of raising high-order multiples. And you've talked about the stresses on the marriages. So you really take seriously the; what's the oath? Help me, here. Dr. Dave Kreiner: The Hippocratic Oath. Don't do harm. Pamela Madsen: Don't do harm. And I think that's really and truly amazing. [text on screen] To Learn More Visit: www.thefertilitydoc.com www.thefertilityadvocate.com For a Free Fertility Consultation Visit: www.eastcoastfertility.com

Video — Journey to the Crib Episode 2: Advances in the Field

Source: East Coast Fertility
Dr. David Kreiner, a fertility doctor and founder of East Coast Fertility, in Long Island and Brooklyn, New York, and Pamela Madsen, Fertility Advocate, discuss advances in fertility treatment.

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[text on screen]: Journey to the Crib. Fertility Talk with Pam and Dr. Dave Pamela Madsen: Hi. I'm Pamela Madsen, and welcome to another segment of Journey to the Crib. And I'm here with Dr. Dave Kreiner, who is the founder of East Coast Fertility. Thanks for joining us! [text on screen]: Episode 2: Advances in the Field Pamela Madsen: When we were talking together last time, Dave, you were talking about the advances in the field. And I was curious about how those advances have changed the way you practice medicine today at East Coast Fertility. Because you were talking about the fact that it's much more successful today. Dr. Dave Kreiner: Yes. Back in 1985 when I first started in IVF we had to transfer six embryos at a time in order to get a 15 percent pregnancy rate. And that was the best in the world. Unfortunately, patients would often try one, two, three, four times before they would be successful in achieving a pregnancy. And when they did, they sometimes had multiples, even triplets and quadruplets. So, that we can today be much more successful with even one embryo is tremendous. And avoid the risks of multiple pregnancies. Pamela Madsen: I'm really impressed with the single embryo transfer program that you've very quietly been doing here at East Coast Fertility for several years now. Can you tell me a little bit more about that. Dr. Dave Kreiner: We have patients go through a single IVF cycle. They pay for just the one cycle, and then everything after that is free. Freezing; the embryo freezing is free. The storage of the embryos is free. And they can come back an unlimited number of times to have these frozen embryo transfers until they're successful with the pregnancy and have a baby. Pamela Madsen: To me this is just so extraordinary, because I can't tell you how many conferences I attend with all the world-class doctors like yourself getting up and speaking. And pontificating, actually, about how important it is to have single embryo transfers. But they don't do anything to help the patient actually do single-embryo transfers. Because for the patient, who's paying out-of-pocket, they have to pay that one fee. Why would they want to transfer one embryo and what are they going to do with all those other embryos? Then they have to pay for freezing. They have to pay for storage. And they have those fears around, "If it doesn't work this one time, how am I going to pay for it next?" And the single-embryo transfer program that you've developed really takes that burden away from patients, and I think it's incredibly unique and important. So, you know, bravo! [text on screen] To Learn More Visit: www.thefertilitydoc.com www.thefertilityadvocate.com For a Free Fertility Consultation Visit: www.eastcoastfertility.com

Video — Journey to the Crib Episode 1: Introducing Dr. Kreiner

Source: East Coast Fertility
Introducing Dr. David Kreiner, a fertility doctor who is the founder of East Coast Fertility in Long Island and Brooklyn, New York.

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[text on screen]: Journey to the Crib. Fertility Talk with Pam and Dr. Dave Pamela Madsen: Hi. I'm Pamela Madsen, and welcome to another segment of Journey to the Crib. And I'm here with Dr. Dave Kreiner, who is the founder of East Coast Fertility. Thanks for joining us! [text on screen]: Episode 1: Introducing Dr. Kreiner Pamela Madsen: You and I have been around this field for such a long time. Probably longer than we want to admit to on television. So, tell me a little bit about where you came from. Dr. Dave Kreiner: In 1985, I had the great fortune to do my fellowship in reproductive endocrinology and infertility at the world-famous Jones Institute in Norfolk, Virginia. The Jones Institute had been successfully performing IVF for five years or more, and people knew about the Jones Institute and came from all over the world because we had a world-leading 15 percent pregnancy rate. Pamela Madsen: My sister went there! It was the only place in the country to go. I think you actually may have treated her. Dr. Dave Kreiner: Yes, I did. Pamela Madsen: So, it didn't matter. It wasn't like you went across the street for an IVF center, like today. Dr. Dave Kreiner: People came from all over the world. Pamela Madsen: Right. So, that's where you started. During that time. Dr. Dave Kreiner: Things were quite different then, Pamela. Back then, IVF was very inefficient and we had to transfer many embryos. Pamela Madsen: What's also changed in the field? Dr. Dave Kreiner: Over the years, we have improved many of the technologies. We started doing laparoscopic retrievals. We now do them under ultrasound guidance, just by needle aspiration through the vagina. We do a much more sophisticated IVF in the lab. We have media that are; the environment in which the embryo grows is much healthier, and is able to encourage much healthier development of the embryos, hence developing embryos of much higher pregnancy potential. Pamela Madsen: What I love about you, Dave, is that you are really not ego-driven. I mean, many people wouldn't realize that many of the quote-unquote "famous" celebrity reproductive endocrinologists around the country were trained by you. And you have continued to be very quietly a thought leader and have taken a lot of these ideas that you've talked about just now into practice to really change the way fertility care is delivered in this country in a very patient-directed way. And that's really extraordinary. [text on screen] To Learn More Visit: www.thefertilitydoc.com www.thefertilityadvocate.com For a Free Fertility Consultation Visit: www.eastcoastfertility.com

Journey to the Crib Episode 9: Fibroids

Source: East Coast Fertility
In this episode of Journey to the Crib, Dr. David Kreiner, a fertility doctor and the founder of East Coast Fertility, and Pamela Madsen, Fertility Advocate, discuss fibroids and their impact on fertility.

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[text on screen]: Journey to the Crib. Fertility Talk with Pam and Dr. Dave Pamela Madsen: Hi. I'm Pamela Madsen, and welcome to another segment of Journey to the Crib. And I'm here with Dr. Dave Kreiner, who is the founder of East Coast Fertility. Thanks for joining us! [text on screen]: Episode 9: Fibroids Pamela Madsen: So, my girlfriend called me last night. She called me because she was really upset that her gynecologist felt masses in her uterus and she thinks that she has fibroids and she doesn't know what they're gonna do to treat her, and is she going to be able to have a baby, is she going to have to have a hysterectomy, and she was really, really scared. So, what are we going to tell my girlfriend and other women who, you know, get diagnosed with fibroids? Dr. Dave Kreiner: Fibroids can be broken down into several different aspects: The location of the fibroid, which can be inside the uterine cavity. It is a much more detrimental factor on fertility than a fibroid that's on the outside part of the uterus or just in the muscle wall but away from the uterine cavity. So, location of the fibroid is key. The size of the fibroid and the number of fibroids may also play a role. A woman's age plays a role here. So, every case has to be individualized. Pamela Madsen: Yeah, because I've heard, like, some women, getting the fibroids removed before doing IVF, and other women their doctors telling them to leave the fibroids in their uterus. Is one wrong? Dr. Dave Kreiner: There are cases where I would feel much more comfortable taking the fibroid or fibroids out before doing the embryo transfer. But if a woman is older and I don't want to wait the six months for the uterus to heal, what I'll do with that patient is I'll do the IVF and freeze her embryos. So we get the eggs out before she gets older, we do the surgery, let the uterus heal, then, when the uterus is healed, we can do the embryo transfer using the younger eggs. Pamela Madsen: You're very clever. I wouldn’t have even thought about that. So, you do the IVF, you freeze the eggs, you take care of her surgeries, and then you put them back in. Dr. Dave Kreiner: We freeze the embryos; right. Pamela Madsen: I'm going to go call my girlfriend right now. [text on screen] To Learn More Visit: www.thefertilitydoc.com www.thefertilityadvocate.com For a Free Fertility Consultation Visit: www.eastcoastfertility.com
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