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Video: When and How Does Fertility Decline?

Dr. Eric Flisser, a New York fertility doctor with Reproductive Medicine Associates (RMA) of New York, explains how egg quality, egg quantity, and age affect a woman's fertility.

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0:00:00.000,0:00:05.000 (text on screen): Ask the Expert 0:00:05.000,0:00:07.000 Fertility Authority. Your Most Trusted Source 0:00:07.000,0:00:12.000 When and how does fertility decline? 0:00:12.000,0:00:18.000 Eric Flisser, M.D., Reproductive Medicine Associates of New York: So, it's a difficult reality that human reproduction is limited. 0:00:18.000,0:00:25.000 And, primarily, it's limited because the number of eggs that a woman has is a finite resource. 0:00:25.000,0:00:30.000 And even since before she was born, a woman is losing her eggs. 0:00:30.000,0:00:33.000 At the peak, a woman has about five to six million eggs. 0:00:33.000,0:00:37.000 By the time she's born, there are about two to three million left. 0:00:37.000,0:00:42.000 And then by the time she reaches puberty, even before she's ovulated even a single egg, there are only about 500,000 left. 0:00:42.000,0:00:48.000 So, about 90 percent of all of the eggs that a woman starts with are gone by the time she reaches puberty. 0:00:48.000,0:00:54.000 And with only one exception that I can think of, there's really no way to stop that loss of eggs. 0:00:54.000,0:01:00.000 Whether a woman is pregnant or she's on the birth control pill, that process is basically unstoppable. 0:01:00.000,0:01:05.000 And as the number of eggs dwindles, the quality of those eggs gets worse as well. 0:01:05.000,0:01:10.000 So, not only are there fewer remaining, but they don't work as well as they had when a woman was younger. 0:01:10.000,0:01:17.000 And that is, primarily, the major obstacle to fertility when there are no other medical problems. 0:01:17.000,0:01:22.000 Female fertility certainly reaches its peak somewhere in the, probably, late teens and twenties, 0:01:22.000,0:01:30.000 and then begins to take a significant decline in the mid-30s, and certainly by 37, 38 an even more significant decline. 0:01:30.000,0:01:36.000 And it's basically impossible for us to predict who will get pregnant or when they will get pregnant. 0:01:36.000,0:01:43.000 We can only observe the population at large and see that as women get older, fewer and fewer are getting pregnant at any given time. 0:01:43.000,0:01:51.000 If, after 12 months of trying, in a woman who's younger than 35, or after six months of trying in a woman who's over 35, 0:01:51.000,0:01:58.000 conception has not occurred, that would be an appropriate time to see a reproductive endocrinologist for a full fertility evaluation. 0:01:58.000,0:02:02.000 (text on screen): Ask the Expert 0:02:02.000,0:02:03.000 Fertility Authority. Your Most Trusted Source

The Clomid Challenge Test

The Clomid Challenge Test (also know as the clomiphene citrate challenge test, or CCCT) is an infertility blood test to measure a woman’s ovarian reserve — the health of her ovaries and the quality and quantity of the eggs (oocytes) they contain.

Ovarian Reserve

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Long Island Regional Intro

New York is home to one of the largest concentrations of fertility clinics, boasting more than 30 throughout the state. Small in size but dense in population, Long Island offers a number of fertility clinics right in its own backyard. There are five fertility clinics in Long Island, offering everything from basic fertility treatments to more advanced assisted reproduction options. These fertility clinics are either independently run or operate in conjunction with local hospitals or medical systems.

Egg Freezing: Maria Menounos Brings Attention to Preserving Fertility

Celebrity Fertility.jpg
'Extra' co-host goes public about decision to freeze eggs

Maria Menounous, co-host of Extra, has recently gone public about a decision that fertility doctors say is the next wave in reproductive endocrinology: egg freezing to preserve fertility for delayed childbearing.

The 33-year-old celebrity announced her decision on Dr. Drew's Lifechangers and also discussed her decision on Monday's Good Morning America, saying "To me, parenting is the most difficult job in the entire world, and when I do it, I want to be committed, and I want to be 100 percent ready to take it on and be the best mom I can be. Right now, I don’t find myself in that position.”

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Video — Journey to the Crib Episode 8: Polycystic Ovarian Syndrome (PCOS)

Source: East Coast Fertility
Dr. David Kreiner, a fertility doctor and founder of East Coast Fertility, and Pamela Madsen, Fertility Advocate, discuss polycystic ovarian syndrome (PCOS) which is often diagnosed when a woman does not ovulate, has irregular periods, or infertility.

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[text on screen]: Journey to the Crib. Fertility Talk with Pam and Dr. Dave Pamela Madsen: Hi. I'm Pamela Madsen, and welcome to another segment of Journey to the Crib. And I'm here with Dr. Dave Kreiner, who is the founder of East Coast Fertility. Thanks for joining us! [text on screen]: Episode 8: Polycystic Ovarian Syndrome (PCOS) Pamela Madsen: Can you talk a little bit about PCOS and what it means to fertility? Dr. Dave Kreiner: PCOS is characterized by having these numerous, small follicles that can be seen by ultrasound. And in fact, we make the diagnosis based on that ultrasound picture in the presence of either failure to ovulate, irregular menses, or infertility. Pamela Madsen: And some PCOS people have weight issues. Dr. Dave Kreiner: PCOS is caused by a glucose intolerance that will accentuate a woman's response to carbohydrates. Their insulin goes up in response to a carbohydrate meal much higher than normal. This insulin then stimulates a woman's ovaries to produce testosterone. The testosterone, on the other hand, will prevent a woman's ovary from ovulating; prevent regular ovulation and menses and cause infertility. The testosterone can also cause a woman to have increased facial and body hair. It can cause thinning of a woman's hair on her scalp. And it can increase the lipids in her blood. So you mentioned cardio problems can lead to hypertension. And even more than that, the high glucose can lead to diabetes in some cases. Pamela Madsen: So I imagine that it's really important for women, whether they're trying to conceive or not trying to conceive, to really get a hold of this disorder. Dr. Dave Kreiner: What we like to do is treat with a diabetes drug called Metformin or Glucophage, which improves their glucose tolerance, decreasing the insulin levels, decreasing the testosterone levels. This goes a long way in decreasing the patient's symptoms. But at the same time it's important for them to change their diet, control and limit the carbohydrate intake at any meal, increase their exercise so that they improve their glucose tolerance. Pamela Madsen: So, if I'm a woman with PCOS, am I going to have a more difficult time doing fertility treatments like in vitro fertilization? You know; how do I stack up? Dr. Dave Kreiner: What a PCOS patient has that many of our other patients don’t have is number of eggs. So, a PCOS patient has so many follicles that we worry more about hyperstimulation than we do failure to recruit sufficient eggs to get high-quality embryos. Pamela Madsen: OK, so, if I'm a woman with PCOS and I've got to deal with acne and I've got to deal with not eating cupcakes and exercising, the good news is that I'm really treatable if I want to have a baby. Dr. Dave Kreiner: Absolutely. Pamela Madsen: Love that! OK. If I've gotta give up the cupcakes. [text on screen] To Learn More Visit: www.thefertilitydoc.com www.thefertilityadvocate.com For a Free Fertility Consultation Visit: www.eastcoastfertility.com

Video: Journey to the Crib Episode 10: Egg Donation

Source: East Coast Fertility
In this episode of Journey to the Crib, Dr. David Kreiner, fertility doctor and founder of East Coast Fertility, and Pamela Madsen, Fertility Advocate, discuss the reasons women use egg donation to have a baby.

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[text on screen]: Journey to the Crib. Fertility Talk with Pam and Dr. Dave Pamela Madsen: Hi. I'm Pamela Madsen, and welcome to another segment of Journey to the Crib. And I'm here with Dr. Dave Kreiner, who is the founder of East Coast Fertility. Thanks for joining us! [text on screen]: Episode 10: Egg Donation So, sometimes, Dr. Kreiner, we can't use our own eggs. You know, time has passed us by, or time was unfair and we have premature ovarian failure or we've had cancer and things happen; we're born without eggs. There's lots of reasons why sometimes we can't use our own eggs. And many women, therefore, make the leap to ovum donation or egg donation. When do you usually counsel women to make that leap? Dr. Dave Kreiner: It's very difficult and I try to counsel patients all along the way, including when I first see them and after each attempt hat may be unsuccessful I would counsel them about their chances of conception and having a live birth and the alternative of egg donation. Always, egg donation is going to give you a far better chance. In our program, we have better than 55 percent live birth rate per donated cycle. Pamela Madsen: Because they're young donors. Dr. Dave Kreiner: They're young donors and they're fertile and we, you know; we'll tell a patient who is older, we'll tell a patient who has an elevated FSH, we'll tell a patient who has stimulated with very few follicles, very few eggs, maybe few healthy pregnancy potential embryos, that there is this alternative of egg donation. Some patients are willing to listen to it and consider it, and some aren't. And that's why we keep; we have to discuss this at every step of the way because there are patients who, at one stage, are not willing to accept egg donation, yet are very willing and interested at another stage. Pamela Madsen: If you're being denied the opportunity to go through that process of giving birth as a woman, you feel left out of that club. The opportunity to try to nurse a baby, those are things … and prenatal care. You know, being the custodian of your babies. Dr. Dave Kreiner: You know, a lot of my patients have voiced the concern that they would not become attached to this baby that did not have a genetic link to them. Pamela Madsen: Right. Dr. Dave Kreiner: I have done this hundreds and hundreds of times and not once did the resulting mother ever think that this was not her baby. Pamela Madsen: Right, because that baby that's put in her arms is her baby. Dr. Dave Kreiner: Yes. [text on screen] To Learn More Visit: www.thefertilitydoc.com www.thefertilityadvocate.com For a Free Fertility Consultation Visit: www.eastcoastfertility.com
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Fertility Doctor of the Month: David Kreiner, M.D., F.A.C.O.G.

East Coast Fertility, Plainview, NY

David Kreiner, M.D., FACOG, East Coast Fertility, Plainview, NY

August 2011

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Video: How Do I Know if I Am Ovulating?

A regular menstrual period is a good indication you are ovulating, according to Dr. Eric Flisser, a New York fertility doctor with Reproductive Medicine Associates (RMA) of New York. In addition, certain blood tests and ovulation predictor kits can help determine if you are ovulating.

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0:00:00.000,0:00:05.000 (text on screen): Ask the Expert 0:00:05.000,0:00:07.000 Fertility Authority. Your Most Trusted Source 0:00:07.000,0:00:12.000 How do I know if I'm ovulating? 0:00:12.000,0:00:18.000 Eric Flisser, M.D., Reproductive Medicine Associates of New York: The only real proof of ovulation, without doing any in-depth testing, is a regular period. 0:00:18.000,0:00:25.000 So, a woman who has a predictable period every, say, 21, to 35 days, is most likely ovulating. 0:00:25.000,0:00:31.000 A period only really comes in an organized way when there's the release of progesterone hormone, 0:00:31.000,0:00:37.000 which is initiated at the time of ovulation, and then when it is withdrawn when no pregnancy results. 0:00:37.000,0:00:40.000 Then that drop in progesterone is what initiates the period. 0:00:40.000,0:00:45.000 So, without any other testing, that's the, really, only kind of rule of thumb that anyone can use 0:00:45.000,0:00:49.000 to determine whether or not they're ovulating regularly. 0:00:49.000,0:00:53.000 Not all bleeding, obviously, is a period, so it can be confusing, 0:00:53.000,0:01:01.000 but it's unlikely that a woman would have irregular, predictable bleeding patterns without having ovulation. 0:01:01.000,0:01:06.000 The additional tests that can be done are, primarily, blood tests. 0:01:06.000,0:01:14.000 You can look at the progesterone level after the date of expected ovulation to see whether it's risen to a level that is associated with ovulation. 0:01:14.000,0:01:21.000 And then there are some indirect kinds of tests that can be done which don't necessarily prove ovulation, 0:01:21.000,0:01:25.000 but can be very helpful, like using a home ovulation predictor kit. 0:01:25.000,0:01:32.000 And those are urinary tests, or sometimes skin tests, that can be used to predict the LH surge, 0:01:32.000,0:01:35.000 which is the brain hormone that triggers the release of the egg. 0:01:35.000,0:01:42.000 If a woman can consistently pick up the LH surge at a predictable time each month, then it's also likely that she's ovulating. 0:01:42.000,0:01:45.000 While that's clearly not proof of ovulation, and there are some medical conditions 0:01:45.000,0:01:51.000 in which the LH surge can be mistaken for just a constantly elevated LH level. 0:01:51.000,0:01:56.000 The primary one is polycystic ovary syndrome, where LH levels can be abnormally high 0:01:56.000,0:02:00.000 and sometimes reach the threshold of the urine test and turn the test positive. 0:02:00.000,0:02:09.000 And, certainly, perimenopause and menopause are also associated with high LH levels, in which case the tests will be positive every day. 0:02:09.000,0:02:15.000 Normally, that test would only be positive for approximately 36 to 48 hours. 0:02:15.000,0:02:19.000 (text on screen): Ask the Expert 0:02:19.000,0:02:20.000 Fertility Authority. Your Most Trusted Source

Video — Journey to the Crib Episode 9: Fibroids

Source: East Coast Fertility
In this episode of Journey to the Crib, Dr. David Kreiner, fertility doctor and founder of East Coast Fertility, and Pamela Madsen, Fertility Advocate, discuss how the size, number and location of fibroids impact fertility.

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[text on screen]: Journey to the Crib. Fertility Talk with Pam and Dr. Dave Pamela Madsen: Hi. I'm Pamela Madsen, and welcome to another segment of Journey to the Crib. And I'm here with Dr. Dave Kreiner, who is the founder of East Coast Fertility. Thanks for joining us! [text on screen]: Episode 9: Fibroids Pamela Madsen: So, my girlfriend called me last night. She called me because she was really upset that her gynecologist felt masses in her uterus and she thinks that she has fibroids and she doesn't know what they're gonna do to treat her, and is she going to be able to have a baby, is she going to have to have a hysterectomy, and she was really, really scared. So, what are we going to tell my girlfriend and other women who, you know, get diagnosed with fibroids? Dr. Dave Kreiner: Fibroids can be broken down into several different aspects: The location of the fibroid, which can be inside the uterine cavity. It is a much more detrimental factor on fertility than a fibroid that's on the outside part of the uterus or just in the muscle wall but away from the uterine cavity. So, location of the fibroid is key. The size of the fibroid and the number of fibroids may also play a role. A woman's age plays a role here. So, every case has to be individualized. Pamela Madsen: Yeah, because I've heard, like, some women, getting the fibroids removed before doing IVF, and other women their doctors telling them to leave the fibroids in their uterus. Is one wrong? Dr. Dave Kreiner: There are cases where I would feel much more comfortable taking the fibroid or fibroids out before doing the embryo transfer. But if a woman is older and I don't want to wait the six months for the uterus to heal, what I'll do with that patient is I'll do the IVF and freeze her embryos. So we get the eggs out before she gets older, we do the surgery, let the uterus heal, then, when the uterus is healed, we can do the embryo transfer using the younger eggs. Pamela Madsen: You're very clever. I wouldn’t have even thought about that. So, you do the IVF, you freeze the eggs, you take care of her surgeries, and then you put them back in. Dr. Dave Kreiner: We freeze the embryos; right. Pamela Madsen: I'm going to go call my girlfriend right now. [text on screen] To Learn More Visit: www.thefertilitydoc.com www.thefertilityadvocate.com For a Free Fertility Consultation Visit: www.eastcoastfertility.com
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