Video: The Rate of Aneuploidy (Chromosomal Abnormality) in Embryos

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0:00:00.000,0:00:03.000 (text on screen): Fertility Authority. Your Most Trusted Source 0:00:03.000,0:00:05.000 Ask the Experts 0:00:05.000,0:00:10.000 What is the rate of aneuploidy, or chromosomal abnormality, in embryos? 0:00:10.000,0:00:16.000 Matthew Rabinowitz, Ph.D, Gene Security Network: If you look at maternal age from your mid-20s through, roughly, the age of 33, 0:00:16.000,0:00:24.000 you will see about 70 percent of the embryos that survive to day five in an IVF cycle are euploid. 0:00:24.000,0:00:31.000 So, that means 30 percent of your embryos are aneuploid, which means that they have chromosomal copy number problems. 0:00:31.000,0:00:37.000 So, you should have; a healthy person will have one chromosome from their mother, one chromosome from their father, 0:00:37.000,0:00:41.000 so on, 23 pairs of chromosomes; they will have one from each parent. 0:00:41.000,0:00:48.000 If you've gone an aneuploidy, you will have a mismatching number of chromosomes at a particular chromosome number. 0:00:48.000,0:00:55.000 So, for example, trisomy 21, or Down syndrome, is when you've got an extra chromosome 21. 0:00:55.000,0:01:01.000 So, the rates of aneuploidy, even for young mothers, are high: around 30 percent on day five. 0:01:01.000,0:01:08.000 From 33 to about 42, the rate of aneuploidy increases while the rate of euploidy decreases. 0:01:08.000,0:01:18.000 So, whereas you have about 70 percent euploidy up to the age of 33, linearly decreasing to the age of 42, 43. 0:01:18.000,0:01:24.000 At that point, you've got about 10 percent of your embryos euploid, or normal. 0:01:24.000,0:01:32.000 So, it's definitely the case that women from the age 35 to 42 have a lot to benefit from the genetic testing. 0:01:32.000,0:01:37.000 I think more and more people, based on the rates of aneuploidy that we see in younger women as well, 0:01:37.000,0:01:45.000 are recommending that you should consider having genetic testing at younger ages as well. 0:01:45.000,0:01:47.000 (text on screen): Fertility Authority. Your Most Trusted Source