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AMH Reliably Predicts Ovarian Reserve in Obese Women

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A recently published study determined that anti-mullerian hormone (AMH) accurately predicts ovarian reserve in obese woman. Recent data had questioned the reliability of AMH in women who fall in extreme ranges of body mass index (BMI), the researchers noted.

Fertility Centers of Illinois performed a retrospective chart review of 2,963 IVF patients who underwent AMH testing and BMI reporting. “We were focused on trying to find the ways to optimize predictions of how patients would respond to IVF,” says Dr. Jennifer Hirshfeld-Cytron, a reproductive endocrinologist with Fertility Centers of Illinois.

The study showed that regardless of where a patient was on the BMI spectrum – obese, underweight, normal weight – AMH was able to predict the number of eggs retrieved. "There were some potential changes when women had a BMI of greater than 40, but for the most part AMH was reliable across the vast majority of BMI groupings,” she adds.

Normal Weight Obese: BMI > 30
Mean Age 35.9 36.7
Mean AMH 2.30 2.29
Mean BMI 22.9 35.5
Mean # Eggs Retrieved 13.9 13

“AMH is marker that can be utilized to determine stimulation protocols and predict how women are going to respond,” Hirshfeld-Cytron says. AMH is particularly helpful, she says, in determining the best protocol to not over- or under-respond older women who are overweight or obese and don’t have the opportunity to wait and lose the weight before trying to get pregnant.

“There’s mixed data on how IVF outcomes are impacted by obesity,” she adds, “But it’s clear that obstetrical outcomes are. Pregnancy should be cautioned in women who are obese and morbidly obese.”


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