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Endometriosis Does Not Increase Aneuploidy Risk

A recently published study determined that endometriosis does not lead to increased aneuploidy in embryos. Researchers at Reproductive Medicine Associates of New Jersey (RMANJ) took a retrospective look at patients who had their first IVF cycle with comprehensive chromosomal screening (CCS) and had surgical or ultrasound diagnosed evidence of endometriosis. More than 1,000 blastocysts produced by 253 patients with endometriosis were compared, by age, to general IVF patients undergoing CCS. The rate of aneuploidy was equivalent compared to their age matched controls, says Dr. Marie Werner, a reproductive endocrinologist with RMANJ, and a researcher in this study.

Current literature shows an association with endometriosis that might alter the spindle formation in the egg – the innate structure, Werner says. “It’s been suggested that may be one of the reasons that patients with endometriosis fail more often to get pregnant, with the best treatment; they might have a higher proportion of eggs that might not have the right genetics.”

“Maybe there’s a slight impact on eggs, but once those eggs turn into blastocysts, the rate of chromosomal normality is going to be the same. Endometriosis might impact those initial parameters, but once those blastocysts form, it seems like the playing field has been leveled,” Werner says. “That’s what I infer, but more studies are needed to clearly distinguish that.”

Because patients with endometriosis are going to have more difficulty conceiving, IVF is generally the best treatment. “Surgery to eliminate endometriosis can give patients a small boost increase in fertility potential, but what’s even better is their chance of pregnancy once you do something as aggressive as IVF,” Werner explains. In all patients, successful fertility treatment is contingent on a number of variables, including ovarian reserve and age.


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