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Isotonic Lubricants Are Fertility Friendly

by Julie Monacelli

Isotonic personal lubricants, like Pre-Seed and Conceive Plus, are fertility friendly over-the-counter products that will not damage sperm. These lubricants contain the same salts and minerals naturally found in the body. They can be used for intimate sexual encounters, gynecologic exams or fertility interventions that require the introduction of diagnostic devices. Some doctors allow use of fertility friendly lubricants for semen sample collection. Unlike KY, Replens, Durex and Astroglide, which are hypertonic or hypotonic, isotonic products will not harm sperm mobility or motility. Studies have shown that even non-spermicidal lubricants can damage sperm upon contact with them, effectively creating a barrier between the sperm and egg. This can impair your ability to become pregnant.

Non-isotonic lubricants may be reported to cause moderate to severe mucosal irritation, with those of hypo-osmotic/hyper-osmotic composition causing natural vaginal mucus production to stop completely. In fact, some studies have reported tissue damage from use. Allergic reaction can sometimes be attributed to artificial lubricants. Some condoms are pre-packaged with lubricants which are non-isotonic. Nonoyynol-9 may be associated with an increased number of yeast infections.

Pre-Seed was the first bio-compatible lubricant to be tested and confirmed as non-toxic to sperm. This lubricant touts the claims of being “slippery and smooth.” Each lot of Pre-Seed is tested for compatibility with gametes. Pre-Seed can be applied topically with their multi-use tube or internally into the vagina with the applicator. Applicators are not pre-filled with product.

Conceive Plus, newly approved by the FDA, has been released to for sale in the United States. Conceive Plus reports a study with its use actually improved sperm viability by 6% over non-lubricant use. Conceive Plus can either be applied immediately to genitals topically or up to 15 minutes prior to intercourse by use of their pre-filled, single-use applicator. Incidents of bacterial infection may be higher when using the applicator method with either product.

If you have used one or both of these products, which one did you like? Do you have another isotonic product you recommend? Did your fertility doctor recommend one to you? Tell us about your isotonic lubricant use on

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