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Live Births with Egg Freezing Tied to Patient Age and Egg Freezing Method
This week in the journal Fertility and Sterility, researchers presented probabilities of live birth after IVF with non-donor frozen eggs. Some patients freeze their own eggs when embryo freezing is objectionable for religious or ethical reasons, or when their IVF cycle is interrupted.
Researchers from New York Medical College and the University of California Davis analyzed clinical research studies on egg freezing from January 1996 through July 2011 - 2265 cycles undergone by 1805 patients. Studies included reported pregnancy outcomes from cycles using mature, non-donor slow frozen or vitrified eggs from infertility patients treated with intracytoplasmic sperm injection (ICSI) and IVF. They found that live birth rates decreased with increasing patient age regardless of freezing technique, yet live births did occur with eggs frozen with slow freezing as late as age 42 and age with vitrification at age 44.
Women whose eggs were frozen with the slow freeze method before age 30 had a greater than 8.9% likelihood of implantation per embryo; this declined to 4.3% for embryos from eggs frozen after age 40. For vitrification cycles, implantation declined from 13.2% for embryos from eggs frozen at 30 to 8.6% for embryos from eggs frozen at 40.
“These probabilities based on patient age will greatly enhance our ability to counsel women who are considering egg freezing,” says ASRM President Linda Giudice, M.D., Ph.D. “Although the data used here came from infertility patients with different diagnoses of infertility, the information will also be useful to women who want to preserve their fertility in the prospect of gonadotoxic therapies for cancer and other conditions and, we hope, be useful in gaining insurance coverage for the procedure.”