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Should IVF Patients Using Donor Eggs Screen Embryos with PGS?

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The role of preimplantation genetic screening (PGS) in egg donor IVF has been unclear, according to Dr. John Zhang. While success rates using donor egg are generally high because donors are young, a large number of embryos are reported to be aneuploid (abnormal) – as many as 53%. So Zhang and researchers at New Hope Fertility Center looked at 81 egg donation cycles to determine whether PGS would be effective. In the study, 31 patients had PGS and transferred euploid (normal) embryos and 50 did not have PGS on the embryos transferred. The PGS group had a higher implantation rate (72.3% vs. 49.1%) and a higher clinical pregnancy rate (72.5% vs. 46.1%).

However, PGS may not make sense for everyone. “Donors we work with already submit to genetic screening, so running a PGS could be unnecessary,” Zhang says. “However, if the donor is over 30, or the recipient wants to check for chromosomal abnormalities, or do gender selection (a natural byproduct of this test) then we will advocate for PGS.”

“Based on the present study, however, we recommend PGS even with donor eggs as an option for patients. We will pass the information on, and let them make an informed decision,” he explains.


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