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The Power of IVF with Pre implantation Genetic Screening (PGS)

a blog by Dr. Michael DiMattina, Dominion Fertility, March 5, 2015

Here is an interesting patient of mine who used PGS, taking advantage of the cutting edge reproductive technologies available today to have a healthy baby. Now, she is gearing up for her second pregnancy again using IVF and PGS. Here’s her very fascinating story.

My patient is a healthy 30-year-old female who first consulted with me in July 2013 for treatment of her primary infertility of a three-year duration. Her mother had five miscarriages before conceiving her apparently healthy daughter, my patient. Her chromosomes were tested shortly after birth and she was found to have a balanced chromosomal translocation, meaning that she had all of her normal chromosomes but some were in the wrong location. This predisposes couples to infertility and a greatly increased risk for miscarriages or worse. So, PGS to the rescue!

She underwent stimulated IVF and we retrieved 12 ova, which resulted in five embryos, all of which were tested using PGS. Only 1 of the 5 embryos was genetically normal. This embryo was easily transferred resulting in the birth of her healthy, genetically normal baby. Yeah!!!

What we learn here is that without embryo biopsy and PGS, she would have potentially undergone five embryo transfers unnecessarily and only one of those transfers would have resulted in a genetically normal baby. This is the power of PGS.

Now, patients, especially those 35 years old and older, are routinely requesting PGS in their IVF treatment to increase the likelihood for implantation and decrease the incidence of miscarriage and genetic abnormalities (Down’s Syndrome being the most common). PGS also makes sense in those patients who have repetitive pregnancy loss, those who have failed more than two IVF embryo transfers and in those couples with unexplained infertility.

The technique is very safe and now extremely accurate too. Refinements in embryo biopsy with blastocyst biopsy of the trophectoderm (the trophectoderm later forms the placenta) over the past few years have tremendously improved the PGS technique. Furthermore, the price for the procedure has greatly fallen and I believe will continue to fall as more genetic laboratories are now performing PGS.

Healthy, and now genetically normal babies! What’s not to like?


Comments (1)

I found Dominion Fertility after suffering multiple early miscarriages. I was doubtful anything could help me have a baby, but Dr. DiMattina recommended IVF with PGS even though I'm only 31 and my husband is 32. We did one cycle and got 13 eggs, 7 fertilized normally, but only one embryo tested normal and she is the most amazing baby. They know what they are doing and even though I was reluctant to use such extreme measures, it was totally worth it.

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