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Fast Comprehensive Chromosomal Screening Will Help Success of IVF, SET

A new study has demonstrated that an optimized method of comprehensive chromosomal screening (CCS) the first technology capable of accurate aneuploidy screening (screening of embryos for abnormal number of chromosomes) of all 24 chromosomes in just four hours. The research was conducted by Reproductive Medicine Associates of New Jersey and (RMANJ) and is published in the April 2012 edition of Fertility and Sterility.

CCS is a term used to refer to a type of preimplantation genetic screening that allows for the evaluation of all 23 pairs of human chromosomes on a single cell with quantitative real-time polymerase chain reaction (qPCR), SNP or CGH. The method of CCS studied by the researchers allows for same-day screening of chromosomal abnormalities with a fresh embryo transfer in in vitro fertilization (IVF). Typically, with CCS, the patient has to undergo a frozen embryo transfer because of the length of time it takes to get the results back.

By screening embryos for chromosomal abnormalities, fertility doctors can transfer the healthiest embryo during IVF with the goal of a higher success rate and a healthy singleton pregnancy.

"Results of the present study have demonstrated the validity of a new rapid method of preimplantation-stage DNA analysis in human blastocysts," says Richard T. Scott, M.D., a fertility doctor with RMANJ. "This advanced embryo screening technique has significant implications for the future of IVF. Using CCS we are able to increase implantation rates, dramatically reduce miscarriage rates, and also reduce the need to transfer multiple embryos to achieve conception. The ultimate reproductive medicine goal of 'one embryo, one healthy baby' is now one large step closer to fruition."

The study was designed to measure the consistency of quantitative real-time polymerase chain reaction (qPCR) diagnosis of chromosomal abnormalities compared with either conventional karyotyping of cell lines or microarray-based diagnoses of human blastocysts. The results indicated that the screening method and the subsequent transfers of blastocysts with no aneuploidy resulted in an increase in the success of IVF. In addition, a retrospective study using this technology demonstrated improved delivery rates and reduced miscarriage rates after single embryo transfer.

"There is a significant health and economic impact associated with increasing the number of singleton births by maximizing the success of single embryo transfer in IVF," Scott says.

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