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Should I Try IVF Again to Get Pregnant or Not? Sperm and Embryo Quality

a blog by Mylene Yao, M.D., CEO and Co-Founder, Univfy, Inc., July 16, 2013

My last IVF did not work; is it time to try a donor egg cycle? I did IVF last year and now I am 40; is it too late for another IVF cycle? If you are asking yourself these questions, you can use your current personal medical information and data from your past IVF cycles for a more personalized prediction of whether your next IVF cycle is likely to work. You can access this test online or at your doctor’s office.

In the last post, we introduced you to the science behind Univfy IVF Prediction Tests to determine your chance of pregnancy with your first IVF cycle (Univfy PreIVF) and your next cycle (Univfy PredictIVF). Both these tests are based on research originating at Stanford University and validated at leading IVF clinics. Our research, based on thousands of IVF cycles, identified key fertility factors that impact a patient’s chances of pregnancy and live birth with IVF. Analysis of these key factors led to the development of a validated statistical model and several IVF prediction tests.

Some of the key fertility factors identified include age, ovarian reserve, BMI, and male partner’s sperm quality. The bottom line is that Univfy’s research shows that your actual chance of pregnancy may be significantly different than that predicted by age alone. The ability to consider each individual’s personal mix of fertility factors against outcomes from tens of thousands of other patient cycles gives strong predictive power to Univfy IVF Prediction Tests.

Univfy PredictIVF uses data from your previous IVF cycles to fine-tune your personalized prediction of success with your next IVF cycle. Your past IVF history (number and outcomes of your previous IVF cycles) contributes 8% to your overall probability of pregnancy with your next IVF.

Your male partner’s data is also considered to predict your overall fertility. If your partner has enough sperm that can swim vigorously in a straight line, your eggs are more likely to be fertilized. Having more fertilized eggs increases your chances that some of these will develop into healthy embryos that can implant and go to term. Both Univfy PreIVF and Univfy PredictIVF use total motile sperm count information from your partner’s semen analysis.

Even when sperm injection (ICSI) is used to inject a single sperm into an egg to bypass issues with sperm number and motility, total motile sperm count in the ejaculate persists as a predictive fertility factor for IVF success. Because total motile sperm count as an indication of sperm quality contributes to both fertilization success and embryo quality, this data is considered in both the Univfy PreIVF and Univfy PredictIVF tests. Also since sperm quality is significant in IVF success, in some cases using donor sperm may result in gains both in the number of eggs fertilized and the number of healthy embryos produced.

Evidence of embryo quality is based on both how normal embryos look and how well they grow over time in culture. Past embryo quality is a factor that contributes 25% to your overall chance of pregnancy with your next IVF. If you had multiple good quality embryos in your last IVF cycle, that bodes well for future IVF cycles.

Although women over 35 as a group may have a lower chance of pregnancy than women in their 20’s, any individual woman in the older age group may have more positive than negative fertility factors, so that her overall chance of pregnancy with IVF could be much better than expected based just on age.

You can find out more about Univfy PreIVF and PredictIVF and how you can use them to help you make tough treatment decisions on our website.

Mylene W. M. Yao, M.D., Co-founder and CEO, Univfy Fertility Prediction


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