High levels of SGK1 enzyme linked to infertility, low levels to miscarriage
British researchers have discovered a link between an enzyme and infertility and miscarriage. Enzymes are proteins that increase the rates of chemical reactions. This enzyme, called SGK1, acts as a type of "fertility switch," with high levels linked to infertility and low levels linked to miscarriage.
The study, published in Nature Medicine, examined tissue samples from the uterine lining, which were donated by 106 women who were being treated at Imperial College Healthcare NHS Trust either for unexplained infertility or for recurrent pregnancy loss. The women with unexplained infertility had been trying to get pregnant for two years or more, with the common reasons for infertility being ruled out. Researchers found that the uterine lining in these women had high levels of the enzyme SGK1.
The researchers found more information from experiments with mice. Levels of SGK1 in the womb lining decline during the fertile window in mice. When the researchers implanted extra copies of the SGK1 gene into the womb lining, the mice were unable to get pregnant. This suggests that a fall in SGK1 levels is essential for making the uterus receptive to embryos.
Up to 400 miscarriage test errors occur in the UK every year, leading to the deaths of too many babies who are aborted, often because doctors are too hasty to diagnose miscarriage rather than carry out a second ultrasound scan, researchers from Imperial College London revealed in Ultrasound in Obstetrics and Gynaecology. More babies die in this way in the UK than from cot deaths (crib deaths), the authors added.
Angelina Pivarnick had a rough time in the "Jersey Shore" house. Sadly, things only got worse once she left. Pivarnick, who left the MTV reality show after two seasons, revealed on the "Father Albert" talk show that she suffered a miscarriage, blaming the intense media glare for causing the stress that lead to it.
Model and actress Kelly Brook has lost her baby five months into her pregnancy. But the model and actress is not the only celebrity to have suffered the trauma of a late miscarriage in recent months. Recent research published in medical journal The Lancet shows Britain has one of the worst records for stillbirth, ranking 33 out of 35 high-income countries. Eleven babies are stillborn every day in Britain.
Study finds the hormone benefits women with a short cervix
One of the risk factors for having a premature baby is a short cervix, the part of a woman’s uterus that opens and shortens during labor. Now, researchers have found that treating women with the hormone progesterone reduces the rate of preterm birth before the 33rd week of pregnancy in women with a short cervix.
The National Institutes of Health study also found that infants born to mothers receiving progesterone treatment were less likely to develop respiratory distress syndrome, a breathing complication that often occurs in pre-term babies.
“The data demonstrates that treating women with premature cervical shortening with progesterone gel can significantly reduce the rate of early preterm birth and improve neonatal outcome,” said George Creasy, MD, FACOG, Vice President of Columbia Laboratories, Inc., the makers of PROCHEIVE bioadhesive vaginal progesterone gel. Columbia collaborated with NIH on the study, which was undertaken by physicians in the Perinatology Research Branch at NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development, as part of the 44 medical centers around the world.
Known modifiable risk factors should be controlled
Repeated miscarriages may cause more than the grief of losing a pregnancy. A new study published in the journal Heart has found a strong correlation between recurrent miscarriage and subsequent heart attacks, giving doctors another important indicator for monitoring cardiovascular risk factors for female patients.
According to Dr. Bruce Albrecht, a fertility doctor at Albrecht Women’s Care fertility clinic in Colorado, the results from this study can affect the way in which women are screened for heart disease.
“If we consider women who experience repeated pregnancy losses to be at high risk for cardiovascular disease, then the take-home message is that the known modifiable risk factors of cardiovascular disease should be controlled in these women, even when they are young and have no symptoms of heart disease,” he says.
Celine Dion is talking openly about her miscarriage and mutiple IVF cycles on Oprah.
Celine has many blessings to be thankful for, but in 2009, she also experienced great sadness when she suffered a miscarriage. In the past, Celine has spoken openly about her struggle with infertility and experience with in vitro fertilization.
For those of you who don’t know my “back-story,” it took me seven years and an awful lot of pregnancies – two miscarriages, a full-term stillbirth, and two healthy pregnancies – to achieve my two fabulous little boys. During those seven years of my life I lived with a lot of grief. My first miscarriage was a shock. I had just jumped on the path of yoga and was certain that I had found the magic fertility bullet. So, when the pregnancy ended early, it was definitely not part of the plan. But my new love of yoga and the hustle and bustle of “trying again” helped me heal pretty quickly from that first loss. After another year and a half I conceived again, but sadly after a wonderful pregnancy my little girl, Georgia, died just before her due date.
After that, I didn’t know what to do. Getting back into the “trying to conceive” mindset was awful. I clung to my yoga practice for sanity, but off the mat my life was plagued with a sense of emptiness. Even more devastating, I felt a desperate need to hold on to Georgia. Trying for another child seemed so disloyal – like I was abandoning her. I can remember looking at the tiny can of ashes that came back from the funeral home and thinking that the poetic thing to do would be to scatter her over Lake Michigan. But I couldn’t let go. My mother-in-law even gave me a lovely jar to put her ashes in, but in the end even that didn’t feel close enough. In the end she landed in my husband’s sock drawer. Don’t laugh. It was safe and snuggly in there – and we saw her every day.