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Bust a Myth about PGD/PGS

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Weigh the risks and the benefits

Fertility Myths

I'm having in vitro fertilization (IVF) — why not just go ahead and have the embryos genetically screened to make sure there are no chromosomal abnormalities. It’s really no big deal.

Fertility Facts

How is the Eeva Test different from PGS or PGD?

Unlike genetic screening or testing using an embryo biopsy, the EevaTM Test uses non-invasive, time-lapse imaging of embryos to help determine the best embryo or embryos for transfer during an IVF cycle.

Genetic Testing

Dr. Tina Koopersmith from West Coast Women's Reproductive Center discusses genetic testing during fertility treatments.

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Comprehensive Chromosomal Screening Explained

Comprehensive Chromosomal Screening (CCS) is a type of preimplantation genetic screening (PGS) done in an IVF cycle. CCS allows for the evaluation of all 23 pairs of chromosomes to determine if the embryo is euploid - has a correct number of chromosomes, or is aneuploid - has an incorrect number of chromosomes.

Is Embryo Biopsy Safe for IVF Babies?

In a retrospective cohort study, Colorado Center for Reproductive Medicine compared perinatal outcomes of singleton infants conceived with and without CCS to understand the impact of trophectoderm biopsy on the developmental future of resultant pregnancies. The study found that, “The majority of deliveries occurred at term and there was no difference in infant gender between groups. Mean gestational age and birth weight were comparable between the groups. In fact, the incidence of very preterm birth and large for gestational age was reduced in the CCS group.” The study concluded, “Babies born after CCS present with excellent perinatal growth and health outcomes.”

Is Embryo Biopsy Safe for IVF Babies?

In a retrospective cohort study, Colorado Center for Reproductive Medicine compared perinatal outcomes of singleton infants conceived with and without CCS to understand the impact of trophectoderm biopsy on the developmental future of resultant pregnancies. The study found that, “The majority of deliveries occurred at term and there was no difference in infant gender between groups. Mean gestational age and birth weight were comparable between the groups. In fact, the incidence of very preterm birth and large for gestational age was reduced in the CCS group.” The study concluded, “Babies born after CCS present with excellent perinatal growth and health outcomes.”

PGS: What Is Preimplantation Genetic Screening?

Preimplantation genetic screening (PGS) is a process of screening embryos to make sure they have the right number of chromosomes and to look for any structural abnormalities in the chromosomes. The process is also called aneuploidy screening. This technique is thought to increase success rates for IVF in women over 35, as well as those who have suffered repeated IVF failure or recurrent miscarriage.

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Study Shows Single Embryo Transfer Successful in IVF Patients up to 42 Using CCS

A Research Study conducted by the Colorado Center for Reproductive Medicine evaluated the efficacy of a single embryo transfer in IVF patients up to age 42, utilizing day 5 embryos (blastocysts) that had comprehensive chromosomal screening, to determine that they were chromosomally normal (euploid).

While the women of advanced maternal age (38 to 42) had a blastocyst aneuploidy rate of 62.4%, as compared to 36.7% in women 37 or younger, following a frozen transfer of a single euploid blastocyst embryo, live birth rates were almost identical in both age groups: 60 percent in women of advance maternal age; 64.6 percent in women 37 or younger.

The ABCs of PGD, PGS and More

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Here's a primer ...

Are you new to an infertility diagnosis or just starting your research on in vitro fertilization (IVF)? Many clinics are offering an array of genetic testing options than can help you have a successful IVF that results in a healthy baby, but the alphabet soup of terms surrounding preimplantaton genetic diagnosis and other genetic testing on embryos can be confusing. PGD, PGS, CCS — what's the difference? Here's our best guide to genetic testing ...

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