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In Vitro Maturation (IVM)

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In vitro maturation (IVM) was first developed in the early 1990’s to provide a safer and cheaper alternative to in vitro fertilization (IVF). IVM techniques are improving, and many fertility clinics throughout the U.S. are beginning to offer it.

How Does IVM Work?

The ovaries are minimally stimulated (meaning less fertility medications are used to make the ovaries produce eggs). Unlike traditional IVF where eggs are retrieved as close to ovulation as possible, IVM captures the eggs much sooner when they are still “immature.” The eggs are “matured” in the laboratory for about 24 to 48 hours using a culture medium containing small amounts of hormones. Once mature, the eggs are fertilized using intracytoplasmic sperm injection (ICSI) – a very tiny needle containing one sperm is directly injected into the egg. The resulting embryos are transferred to the woman’s uterus.

Who Is a Good Candidate for IVM?

As with all fertility treatments, IVM is not considered appropriate for all women. Women who typically benefit the most from IVM include:

  • Women who are at higher risk for ovarian hyperstimulation syndrome (OHSS), including women with polycystic ovarian syndrome (PCOS).
  • Women who are younger and have normal menstrual cycles.
  • IVM can also be used with regular IVF cycles when the stimulation protocol allows for many immature eggs to be obtained as well.

Advantages of IVM

Since IVM requires less fertility medication, this significantly lessens the risk for OHSS, a rare, but potentially serious complication.

IVM is less expensive because it does not involve costly gonadotropin injections and requires less monitoring. On average, an IVM cycle costs about $5,000 to $7,000 compared to $15,000 to $20,000 for traditional IVF.

IVM involves a shorter treatment regimen compared to IVF, meaning a cycle of IVM takes less time than IVF.

What Are the Disadvantages of IVM?

IVM is still relatively new, and the overall success rates and long-term outcomes of IVM are unclear. Because the eggs collected via IVM are extremely sensitive, they need to be handled very carefully in the lab or risk losing them. Also, the outer part of these eggs can become tough for sperm to penetrate making ICSI required.


Comments (20)

I am a cancer survivor and only tissue could be rescued Is anyone running any free studies? Thanks

Hi my name is Amanda and I'm from Los Angeles and I've been looking for IVM I get pregnant normally I have three girls I just want to Gander selection i want to boydo I can found dr on LA

Hi Amanda,

We can help you find a doctor that specializes in IVM. Give us a call at 1-855-955-BABY (2229).


I do know of IVM trial in NYC. Neway Fertility is looking for 11 couples to work with--and is providing all WORK FOR FREE. Must have PECOS, tho... call 212-750-3330

Hi Jason, You can check out Best, Kim

Hi, I'm 33 years old, i married since 7 years i tried the ivf three times, but my eggs cannot be fertilized because they are abnormal and some of which can not complete their divisions, is the IVM is best in my case

Hi Rana, I am not a doctor, but it seems like IVF with ICSI and PGD would be a better treatment option for you. If you yield very few eggs from an IVF cycle, then mini-IVF or IVM may be an option for you. ICSI will help with the fertilization and PGD will allow the embryologist to select the most normal embryos for transfer. Give us a call at 1-855-955-BABY (2229) if you would like to connect with a fertility doctor near you who specializes in PGD or IVM. Best, Kim

Hi I have 32 years and I have tubes ligation about 6 years ago but my menstrual cycle is normal, this treatment will be right for me?

Hi Maria, IVF or IVM could be the way to go if you are not interested in a tubal ligation reversal. Give us a call at 1-855-955-BABY (2229) and we will connect you with a fertility doctor in your area. Kim

If my husband and i are fertile but have had a tubaligation and a vasectomy. What procedure would work best for us. We are newly married and want to have a baby together

Hi i am a 25 years old trying to get pregant can anybody help me please.............

I have had a couple of surgeries for my fibroids and endometriosis. I wanted to know if I would be a candidate for ivm being that I am 39 years old with these issues or should I stay focused on ivf? Thank you

Hi Celestine - I can't give you medical advise. I would suggest a consultation with a reproductive endocrinologist or fertility doctor in your area. S/he can do a fertility workup and determine the best treatment option for you. Because you are 39 years old, and we know that egg quantity and quality declines with age, it's important to see a fertility doctor sooner rather than later.

Let me know if you'd like more information.


i am 44 years old and my hubby is 49. we have been ttc for 6 yrs and no luck. my hubby has a very low sperm count and i have fibroids, we are thinking of ivf. what is the age limit for ivf? are there finacial help for that?



Hi Lydia - I'm sorry you have been having a hard time getting pregnant - 6 years is a long time! You're right, most fertility clinics do have an age limit for IVF, and you are at the top of that range - the chances of success with IVF decrease with age. You should definitely schedule a consultation with a fertility clinic right away to find out what your options are! Many fertility clinics do have financing programs. Take a look at this section on fertility treatment costs.

And use the Find an Expert search on FertilityAuthority to find a fertility clinic near you.


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