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Blood-Clotting Disorders: How They Affect Your Ability to Get Pregnant

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Normally, a small cut on a blood vessel wall causes the body to form a blood clot to seal it and stop the bleeding. However, some people form blood clots too easily. If you tend toward excessive blood clotting or if the clots don’t dissolve properly, you’re said to have a blood-clotting disorder.

Several things can alter the body’s normal blood clotting process. For example, smoking, plaque on the inside of the arteries (atherosclerosis), and birth control pills can increase the risk of excessive blood clots.

Pregnancy can also lead to excessive blood clotting. Since more clotting factors are in a woman’s blood during pregnancy, a pregnant woman is six times more likely to develop blood clots. Also, because the uterus compresses the veins during pregnancy, the blood flow slows down as it moves through the vessels and may lead to blood clots.

What Causes Blood Clotting Disorders?

A blood clotting disorder is a result of the body making either too many blood clotting factors or too few anti-clotting factors that limit clot formation.

Excessive blood clotting may be caused by genetic disorders which are inherited from one or both parents. Two common disorders are “factor V Leiden” and “prothrombin mutations.” They increase the risk of developing a potentially dangerous blood clot which could travel to other parts of the body. They may also cause small blood clots to develop within placenta tissue which could lead to a miscarriage.

Some blood clotting disorders are due to problems in the immune system. Lupus anticoagulants are antibodies that attack those substances that the body normally produces to prevent blood clotting. People with those antibodies have a high risk of blood clotting.

How Do Blood Clotting Disorders Affect Pregnancy?

Genetic and immune clotting disorders are associated with recurrent miscarriage. If you have factor V Leiden and prothrombin mutations, you may also be at risk of having a placental abruption, which happens when the placenta partially or completely separates from the uterine wall before delivery. This results in heavy bleeding which is dangerous for the pregnant woman and the baby.

Factor V Leiden and prothrombin mutations may also increase your risk of other complications during pregnancy, such as pregnancy-induced high blood pressure and slow fetal growth.

Although most women with these mutations have normal pregnancies, it’s important to talk to your doctor about your own risk of abnormal blood clots and pregnancy complications.


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Comments (104)

I have a 14 year old daughter but I had an extremely difficult pregnancy with her. I want to have another child, I loved being pregnant. Since my daughter I've had DVT, PE and CVA from a clot that formed in my brain. It's a long story as to why I was not on anticoagulants. I finally tested positive for a lupus anticoagulant and a protein s deficiency. I take 25mg of warfarin a day and they keep my INR at 3. Is a pregnancy completely out of the question for me?

Must there be blood clots if i use the medical abortion for a pregnancy that is only five weeks!?and must i bleed for more than a day?

Must there be blood clots if i use the medical abortion for a pregnancy that is only five weeks!?and must i bleed for more than a day?

My first IVF procedure back in 2010 resulted in a healthy baby boy.....although he was 4.5 weeks early, came home right away and was 6 1/2 pounds. December of 2012 IVF resulted in pregnancy....numbers were increasing and I ended up miscarrying on new years eve. Was told it was embryonic. March 2013 same pregnancy. In early June had a chemical pregnancy and Fertility Dr. Ordered a bunch of tests. 19 vials of blood later I was told that everything was good except that I had one clotting disorder and not to worry that I could take baby aspirin once pregnant and would be fine. Got pregnant again in August, but numbers went down. Dr. Never mentioned anything about clotting. Took a break and started seeing acupuncturist for several months. Next procedure is April 4th....and I asked same IVF coordinator about clotting disorder and she acted like it was the first she had heard about this. Grrrrrr! $1400 of out of pocket expense for labwork and they forgot about clot disorder. Reading everything on this, I feel like my Dr. Is all about $ and if I don't do something soon about disorder.....I will have same result.....question- how could I have had a healthy baby boy and three years later, I am facing IVF #5......andI have a clotting disorder? Are there some disorders that baby aspirin is the only remedy.....sounds like most are on major blood thinners......left message for IVF coordinator to find out exact disorder.

Honestly, if I were you I would see another doctor - someone who has experience with blood clotting disorders - and get a second opinion. You definitely need more info, especially to help understand about the miscarriages. Let me know if I can help. Best, Claire

My husbands mom has blood clots, I was wondering if that can affect my baby? I'm 10 weeks pregnant.

I am having wevere bleeding mostly brown old blood but its constan some days its red bleeding than it goes back to me within next 24 hours of passing huge blood clots yet baby and babie heartbeat are fine im almost 9 weeks and have been dealing with this for 7 weeks now i stressed depressed and have been in bed ti weeks i also have tons of cramping due to previous surgeries so i sometimes dint know when to worry at this point so i just worry all the time this baby will be my 3rd but me and my husbands first my youngest is 13 and in the 8th grade but im constantly dizzy since im losing so much blood but the doctors are saying they have jo idea what this could be so im scared and confused and dont know where to go from here orher than crazy..any ideas or feeback or similar experiance that worked its way to a helathy preganancy would love to have sone glimer of a postive

I'm sure that is so scary for you - and I'm glad you are talking to your doctor. You may also want to get a second opinion. If you're looking for some support from other women who are going through the same thing, we have very active forums on All the best, Claire

i was wondering if i am able to get pregnant agian and i and my baby will be ok? I had my son and 5 weeks after i got a blood clot in my leg and then it went to my lung. was taking blood thinner for a year and now i am off of it for 4 yrs. Please could use some adive..

at 7 months, i've been bleeding and had some blood clots. i didn't experience any abdominal pain or cramps. i went to my ob for an ultrasound and didn't find any problems. The baby is ok and my placenta is in good condition, however, I'm still seeing blood clots in my undies everytime I want to pee esp at dawn. I still continue to drink isoxilan but I don't know if it helps. Please enlighten me with my concern as I worry a lot since this is my first baby. Thank you!

I know that must be scary. Have you told your doctor - and let him/her know your concerns? You really should. Best, Claire

i had 3 miscarriages earlier. i went for testing my blood. there r no clots. but still my doc suggested me to go for heparin injection daily till delivery. can i got for it?

I just lost my daughter at 20w two days ago. I am devastated but want to be smart in finding the cause. When the doctors test my placenta will they check for blood clotting disorders or do I need to go to a hemotologist for that? Is time of the essence? I had 3 large bleeds since week six and on and off spotting till she was born which they thought was a hematoma and then placenta previa. but both were ruled out. I also think this caused placental abruption as I have had some detached tissue exit my body since the birth. Please give me advice and direction. . I am fighting to keep my head above water from the darkness I feel. Thank you

Hi Liz, I am so sorry for your loss! My heart aches for you. I do think you could benefit from a meeting with a reproductive endocrinologist (fertility doctor) who specializes in pregnancy loss and clotting disorders. Give us a call at 1-855-955-BABY (2229) or email and we can help advise you further. Best, Kim

Hi Charlotte, I am so sorry to hear of your losses. Have you considered working with a fertility doctor who specializes in immune disorders? They will be able to help you achieve pregnancy and stay pregnant. Give us a call at 1-855-955-BABY (2229) and we will connect you with a fertility doctor in your area. Best, Kim

I am 22 years old and I had my son in April of 2012. He was pronounced stillborn because his heart stopped when I was 25 weeks and 3 days pregnant with him, and at 6 months a baby is considerd viable because they have a 50/50 chance of living if they are born that early. The Dr. said that he out grew the placenta due to inadequate blood flow. They said they don't know how that happened. They sent the placenta to a specialist who said that it could have been because of a blood clotting disorder or preeclampsia but there is not enough evidence to support either theory. They want me to do some blood tests to see if I have a blood clotting disorder, but when I was in the hospital having my son they said that I had great valvey vains and healthy blood which was a good indicator of not having a blood clotting poblem and I didn't have any bad urin samples for them to worry about PIH. Could it just have been a fluke or should I be worried the next time I get pregnant? And if I do get pregnant again and I have a blood clotting disorder, what are my chances of having a healthy LIVING baby? Please, I need reassurement.

I have PCOS and my husband has MFI. My husband also has Factor V which was diagnosed in 06 after a pulmonary embolism. He is now on warfarin and will be for the remainder of his life. We are currently seeking treatment with an endo and are just beginning our third round of IUI with injectables. We have also seen a reproductive urologist. No one seems to know if there is a connection with male infertility and Factor V and/or warfarin. Does anyone else have this problem or have you heard anything about this?

what are your thoughts on lovenox vs. heparin? I have MTHFR hetero C677T. Pregnant 7 weeks 6 previous miscarriages. found out on the 6th pregnancy. 1 shot per day vs. 2 shots per day and why? If you have any info please help.

Ever since I've had a dvt after my delivery in 2006. The doctor told me that each pregnacy I have to be on blood thimners. I have three kids now on my fourth kid still have to be on blood thinners but they don't know why I had a dvt in 2006 and either do I. All I can say is that I was taking birthcontrol in 2004&2005. I was taking yasmin. I took it for those period of time. I found out and Omg I was on birthcontrol and I had to stop it immediately. So I was 6 months pregnant with my first child and the doctor discovered I had a bloodclot in my placenta and if it didn't go away I would have been on blood thimners but it went away. And had a healthy baby girl. I got pregnant in 07 I was 8 weeks pregnant and I started bleeding heavy to wear it didn't stop I thought it was just a period and I didn't think I was pregnant and took a pregnant test came to be positive. I called my doctor and confirm that I had to get a abortion. I was sad but then in august I got pregnant again in 07 and took blood thinner lovenox and delivered a healthy baby girl. I got pregnant in 2010 and took lovenox a healthy pregnancy and baby she is 8 months. So now I have three girls 5,3, and 8 months and now I'm pregnant again with my fourth kid I will do fine. So my advice to every woman that is scared don't be it will always do good in the end. Keep trying cause faith will always be by your side. May everyone that is pregnant wishes you the best and hopefully delivery.

I used Lovenox every day during my pregnancy for a placental blood clot disorder. My baby had no side affects and is 100% healthy. I am posting this so that others who are diagnosed with this condition after experiencing miscarriages will feel more comfortable and at ease when their doctors prescribe Lovenox for them. I gave myself shots in the sides of the stomach daily. It is difficult at first but it does get easier and you become more comfortable with being able to give yourself the shots over time. I had 3 miscarriages due to this disorder but once I was diagnosed and got on Lovenox my pregnancy was as smooth sailing as a pregnancy can be :). xoxo to all of you.

I'm 3 weeks and 6 days and I have discovered spotting at first. It was not on my panties at first then I kept making a trip to the bathroom and all of a sudden when i wiped myself I seen blood clots on the tissue. I got in the shower and when I got out i put on a pad the blood clots was BIG and icky. Does this mean I'm having a miscarriage?

I have Lupus Antibody as well as APS. I also have an antibody to Heprin. So the only blood thinner I can take would be coumadin. I can't have kids because I will die if I try again. But I wanted to try for a sirigant mother? Can I be on hormones to collect my eggs? Is it too risky? would I have to get off coumadin?

I was wondering if anyone could help me...August 14 i found out that my baby died...i was 24 weeks pregnant, i gave birth the next day he was 13 inches long and 1 pound 3 ounces Jaidan...i had had bleeding in the 12th week and sever cramping through out but a seemingly healthy pregnancy. When he was born there was a HUGE clot in the umbilical cord right near his belly button he was really tangled but they say it was the clot that killed him, has this happened to anyone else? Can anyone tell me if they know of a clotting disorder that could have caused this? I want to be prepared so i never have to go through that again...i know yall know how hard it is to lose a child and i pray no one ever has to go through that again or at all. Please let me know if any one has any ideas of what it could be

A blood clot causes problems because it will not allow oxygen and nutrients to get to the baby and this is why women may lose a baby, have a miscarriage, etc. I have a placental blood clot disorder. I imagine this is the same as you, as the umbilical cord is the vehicle so to speak of how the oxygen and nutrients get to the baby.

hi ,i have had eight babies with one misscarriage ,the fourth baby misscarried but i have eight healthy children,didnt know i had factor 11 leiden until third baby,as my sister got dvt in pregnancy ,i got tested as i was pregnant ,through all my pregnancies took clexane injections during pregnancy and baby aspirin until eight weeks after birth,was all great till after my eighth child i had a massive pulmanory embolism ,and am lucky to be alive as sooon as i stopped the clexane i must have started clotting,told not to have any more babies as its too dangerous now ,although she was our last anyway ,but i have four healthy boys and four healthy girls,the clotting was the worst thing to ever happen to me though as i have ,depression,anxiety ,ptsd,and panic attacks, on warfarin indefinately and meds for panic attacks and depression ,

I am going to be 30 next month and have lost 2 babies. The first was a miscarriage at 6 weeks, the second was a placental abruption at 22 weeks. I do have one healthy son that happened between the 2 loses. But, in that pregnacy I had severe Pre-eclampsia and I had to to have an emergency c-section at 36 weeks. I just had blood work done yesterday for blood clotting disorders. While I am waiting for the results I decided to do some researching. I have an amazing High Risk Doc and OB's, but am curious about the meds. Everyone seems to be either on Heparin or Lovenox, which would be better for me when it comes to my next pregnancy?

I took Lovenox and had a wonderful experience. My son is now 14 months and healthy as can be. I would recommend Lovenox. I was 31 when I had my son.

hi yes i am 23 years old and i ended up in the hospital for a week last year after taking birth control pills for 2 and a half months come to find out i have blood clots .well my doc says i have factor 5 and that i CAN NOT EVER GET PREGANT because of my blood clots and me being on warfarin and he told me i have to take it the rest of my life well i dont have any kids and I WANT AT LEAST 1 i always wanted like 4 but since this blood clot thing i wont be selfish so id take 1 just to have my dream come true but he keeps telling me i can not ever have any what should i do he is a good doc but i want a child can somebody please help me ??? and since this has happened it has done nothing but depress me because bfore i used to walk miles a day now i can only make it to the corner store gained alot of weight and it hard to diet because u cant eat salad like that and i feel like an old lady because i cant do the same things i used to do with out my lung hurting due to the clots damanging my really sucks n is really depressing anytime i get hurt i have run to er the er is not a life it sucks just like jail would to an inmate..i want to quit taking my warfarin but the doc said he will put me n phyc ward cuz im tryin kill myself because its a life or death sisuation can somebody please help

I would highly VERY HIGHLY recommend that you find a different doctor, preferably a fertility specialist. I would discuss Lovenox with your next doctor. There are many doctors that do not know anything about blood clot disorders and claim they do. See a good specialist. My doctor was a graduate of Duke University's medical program and I have been to quite a few doctors that graduated from there and were great doctors, including the one that diagnosed my condition and helped me to have a healthy baby boy after I had-had 3 miscarriages before my diagnosis. Many regular OB doctors had no clue and didn't even ever suggest getting tested for a blood clot disorder. I have Factor V as well and I have a beautiful baby boy. I took Lovenox shots daily throughout my pregnancy and for a few weeks after childbirth. xoxo

I am so sorry you are going through this. Are you talking to a reproductive endocrinologist and a fertility therapist? There are many avenues you can explore for building a family, such as adoption and surrogacy. One of these options may be right for you if you are not able to carry a child. Please send an email to if you want to talk further.

Hi everybody
Im 25 and I had two miscarriages so far one at 10w and the other at 8w

When they did the tests for The second one they discovered a trisomy7 , which cannot be controled, they also found that I had low level of protein S/C, factor 7&8, antithrombin3, plasminogen . The genetic counselor said that since I did this tests prior to my D&C they could be wrong so he advised that I should redo them.
I'm very scared and I dunno what to do should I see another doctor or wait for the second blood test I'm afraid specially when I hear about the injections I don't mind them but I'll be scared for the baby and the risks fir both of us

Is the genetic counselor the right doctor for me ? I'm completely lost !



I also had 3 miscarriages due to a blood clot disorder. I took Lovenox shots each day throughout pregnancy. I have a healthy baby boy and I too am healthy. My suggestion would be for you to get a more thorough explanation from this doctor as to why he is telling you that if you get pregnant it could kill you. Just get as much information on that as you can-- ask what type of blood clot you have -- because many times Lovenox is prescribed for a placental blood clot. There are many different types of blood clots. A placental blood clot would be quite different than the type of blood clot that sometimes exists in areas like the heart or leg veins. FYI, my doctor never said anything regarding being able to die if I got pregnant... so either you have a very different type of blood clot disorder than I, or you could see a different specialist and get a second opinion.

I have had 5 miscarriages one at twins at 27 weeks, another at 10 weeks, one at 20 and one at and 5 weeks. Never knew the cause til my dr recently ran tests 3 months and i tested for Factor V Leiden, Thrombophilia. The dr has me taking baby asprin but he said when i become pregnant that i will have to be on heparin. But i had to stop the baby asprin the 7th because now i have to have a laporscopy and some other procedure done to see what else is going on.

What are the chances of having a baby with ET- essential thrombocytosis?? I just had a m/c in Feb and am debating if I should try again. I would hate to have to go thru another M/C. Any advice?

HI im 22 years old and i have a blood clotting disorder. i got a blood clot in my lung when i was 21 from birthcontrol which is how i found out, i spent my birthday in the hospital and it turned out i was allergic to the lovanox so they gave me heprin. i am now 3 months pregnant. My hemotologist put me on 2500mg injections of fragmin once a day at 10 weeks. i am now 13 weeks and everything is fine. the baby is growing normal and everything so as long as i take the shots everyday they say everything should be fine. Reading the comments of the people who have gone through it has comforted me some. Sorry to all of you who have ha losses my only advice is to get a good hemotologist an obgyn. i actually didnt think i coul get pregnant bc my husband an i had tried for a few years. So to all of you with the clotting disorder who want to have kids there is a solution and the shots are safe. It is a miracle from God and if it is a boy i plan to name him Gabriel which means God is my strength bc God is the best solution to any problem and with his strenth we can get through anything. God bless all and good luck!

I have had a still born son 6 weeks exactly before his due date and 6 months later i got pregnant again and lost it at 6 or 7 weeks and my doctor told me i had the clotting disorder i also have the rn factor were my blood is different then the fathers we are planning to try again later in the future and im afraid to get pregnant again but kno that i truly want to hold my baby in my arms it is a terrible thing to hold a son that doesnt make a noise. take the shots im sure itll be worth it

If you are having clotting issues and doctors have no answer, ask to be tested for may therners syndrome. I'm 18 years old and was diagnosed with factor five and may therners, very uncommon but just to get the word out for safety!

Im sorry for yours losses but i have had the same problem. Im 32yr old have a 13yr old never had a problem when i was pregnant with her. 11 years later i got pregnant again at 5 1/2 mths i gave birth to a baby girl she passed 5hrs after. That happen in Jan 2008 i then got pregnant again started bleeding from the start my Doc said everything will be fine. I was placed on bed rest and put in the hospital for 3weeks. Again i gave birth and she didnt make it either. Since then i have had 2 more miscarriages at 3 to 4 mths .. I finally went 2 see a fertility doctor cause i was just 2 the point of closing that door in my life. My other doc i was not happy with it was always next time will be the one. Well i was tested for blood clotting disorder. He feels with all the problems i had and the bleeding from each time i was pregnant i should had been tested along time ago. The last 2 times i lost so much blood i was put in the hospital and had 4 to 5 blood trans and almost died once . I hoping this answers my questions. If so i will try and do the shots twice a day .. Im just praying for once i found out the cause and then also i can not feel as if i did something wrong or not right.. I should found out next week what my results are i cant wait...

I too have have a very similar experience as you. Did the lovenox or heparin 2x/day work. I pray that it did, I'm so sorry if it didn't. I have had 5 miscarriages 1 still born about 7-8 months and after 2years I am pregnant again at 7weeks and a day. I am on 1 baby aspirin, haven't started my lovenox yet waiting for approval from insurance, omega 3 oil, prenatals(but I am going to switch to Neevo which gives a different form of folate for those with blood clotting disorders and multiple miscarriages), folguard(folic acid with b vitamins)also a additional folic acid( to total 2.6mg) I'm also going to take a 2 Sublingual Active B12 with Methylfolate first thing on rising and 2 more before lunch time. All that and prayer. I have MTHFR hetero C677T, everything else was healthy and clear. I didn't find this out until my 6th pregnancy but wasn't taking all of this because doctors were treating it as if it didn't really contribute to any of the miscarriages. Should I be working especially with special needs children or is bed rest the better option? What are your thoughts on all this, it would be greatly appreciated. (0:

i have had a son that is now 13 healthy. since had 4 miscarriages all before 10 weeks, im 32 in the last 6 months or so my peiords have been heavy and clotty and ive been dizzy with frequent nose bleeds. i just went yesterday to an urgent care and they sent my blood to a lab to get tested for a blood clotting disorder, what would this show? would this explain the unexplainable miscarriages?

I am diagnosed with Factor V Leiden (hetero) and Protein S Deficiency- and I am going to see a hematologist in a couple of weeks to get tested for all of the blood clotting disorders (as I have only been tested for those). My dad had clots, my cousin had clots after her baby was born (and has a clotting disorder) and my dad's aunt passed away from a blood clot in her lungs after her baby was born. I have had two miscarriages. One just happened today at 5 weeks, the other was last May at 10 weeks. The first miscarriage I ended up in the emergency room because the doctor said I could pass it at home- and I ended up hemorrhaging grapefruit size blood clots every two minutes for hours, and it was very traumatic. They told me that I could pass this one at home since it was very early. And I am still scared from the first one. The thing I am upset about is the way the doctors seem so nonchalant about the whole thing. They say they do not test women for anything until they have had 3-4 miscarriages. I am 32 (almost 33) and do not want to continue to have miscarriages for years until they start to look at me more closely. Don't you think that someone would pay more attention since I have a blood disorder and blood clots in my family? Help! I feel so helpless and as if they think I am overreacting, but I read all these horrible things about this disorder and I am convinced that is what is the cause. I guess I will hope that my hematologist has some answers and is more understanding of my concerns. My OBGYN said since I have not had any blood clots I am fine (really, so you are going to wait until I do?). I feel as though I need to be standing in their office having the blood clots for them to pay attention to my situation. Sorry if I am upset- it has been an emotional day!

I'm so sorry you are going through this - and miscarriage can be very heartbreaking. You really should be seeing a fertility doctor, rather than an ob/gyn. Many fertility doctors (also known as reproductive endocrinologists) have a lot of experience working with women who have suffered multiple miscarriages. I encourage you to use the Find a Local Expert search on FertilityAuthority to find a fertility doctor in your area. Bring your complete medical history with you to the consultation, and also a list of questions so you and the doctor can address your specific diagnosis and concerns.

In addition, you can find information and support from other women on I encourage you to check in there and connect with other women in a similar situation.

I wish you all the best,

I have Protein S deficiency n I had blood clots after I had my 1st son. I took Lovenox n Heparin while pregnant, but still developed clots. Now we're thinking about having more kids, but have been told it'll be risky. Anyone else going through anything like this??

Hello, my first pregancy resulted in my beautiful now 10 year old son but after that I have had 2 very early term miscarriages, 1 ectopic pregancy, and 1 late term loss (16 1/2 weeks, heart stopped beating). That was 3 years ago and they told me after doing testing that I had a disorder caused my blood to clot too much and they suspect that's where my issues may be from and my doc said he would probably have me take daily injections to thin my blood if I were to conceive again. I looked up the name it was very long and it said alot of people actually have it but it's either benign where there are no symptoms or issues, or it shows up during pregancy. I cannot remember the name and none of the ones in the article are ringing any bells. Does anyone know of anything like this? We are thinking about getting pregant and I would just like to do some research.

Hi, I am 30 years old and i have had 7 miscarriage already in 7 1/2years...the last misscarrge i had was on may 2010, i was almost 3mons. the splecialists told me the next time i get pregnant i will be on lovenux twice a day because they asume that blood disorder is what i have...i am kind of scary because during all this time i have not had any answer for what my problem is after studies and studies...anyways to have a baby i would do everything to be a mom...i was drinking ruda with chocolate as tea everyday for 4 mons. and it works good because now i get my period every 28 days exactly with no pain at i keep trying to get pregnant...

I'm 28 I have 2 children 12 and 4, they were both difficult pregnencies but they survived. In 07 I got PG again with a little boy but started bleeding at 7wks. The drs made me deliver him at 16wks. I had never stopped bleeding and they had seen what they believed was a clot under the edge of the placenta at 9wks. The placenta just kinda grew over it. By the time I delivered I was bleeding alot. again in 09 I got PG and MC at 6wks. I was told to get the clotting tests and what not done but I chickened out and haven;t really wanted to try again so it didnt matter. Now I have been thinking about it so should I ask the dr. to reorder these tests. I'm just scared. I don't know if I can go through another loss.


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