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How Do I Take Clomid with Intrauterine Insemination?

Clomid is a type of fertility drug often used during intrauterine insemination (IUI) to help increase the number of follicles capable of ovulating during the treatment cycle. In turn, it may increase your chance at becoming pregnant. So how should you be taking this drug for the greatest probability of success?

Clomid is prescribed in varying doses depending on the patient’s response to the drug. The tablet is taken orally , typically between days three to seven or days five to nine of your menstrual cycle. This drug stimulates your body’s FSH production, which leads to the growth of your eggs.

Your fertility doctor may instruct you to monitor your ovulation using Ovulation Prediction Kits (OPKs) at home. Ovulation generally occurs between five and ten days after the last dosage of Clomid is taken. Your fertility doctor will perform ultrasounds periodically throughout the cycle to evaluate the growth of egg follicles. If the doctor believes the growth of your egg follicles is adequate—and the eggs have reached maturation— you will be given a shot of human chorionic gonadotropin (hCG) to trigger ovulation. Ovulation will occur about 36 hours after you get that trigger shot.

Your intrauterine insemination process is timed according to your hCG trigger shot. It will take place about 36 hours after hCG is given in order to sync up with ovulation. If the cycle was unsuccessful, you’ll likely get your period about 16 days after your hCG trigger shot. If this period is several days late, contact your fertility doctor—he or she may want to perform a pregnancy test.

Looking for information on what IUI with Clomid is really like? Check out our Intrauterine Insemination (IUI) board on and chat with others who are going through the process.

Wondering if IUI with Clomid of IVF is the better fit for you? Watch this video where Dr. James Goldfarb of University Hospitals Fertility Center in Ohio explains why many infertility patients benefit from IVF if they do not respond well to Clomid and IUI.

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