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What Kind of Fertility Drugs are Used with Intrauterine Insemination?

Intrauterine insemination (IUI) can be timed to match up your body's natural ovulation window, but more often, it’s performed along with fertility drugs for best ovarian response and control over the cycle. The two most common types of fertility drugs used in IUI are clomiphene citrate and gonadotropins.

Clomiphene citrate

Clomiphene citrate, which includes the brand names Clomid and Serophene, are drugs prescribed when woman don’t ovulate or don’t ovulate regularly. The drug stimulates the body to produce higher levels of FSH, or follicle stimulating hormone, which helps the eggs grow and mature.


If you’ve tried clomiphene citrate but were unsuccessful, your fertility doctor may move on to gonadotropin therapy either used together with clomiphene citrate or on its own. Gonadotropins include Follistim and Gonal-F. Administering these types of fertility drugs suppresses the release of luteinizing hormone (LH) and prevents premature ovulation. You can take gonadotropins either by intramuscular or subcutaneous injections. As the drug is absorbed by your body, it stimulates your eggs to develop. With this fertility treatment protocol, you can typically expect three to eight eggs to mature.

Keep in mind that many fertility doctors will cancel your IUI cycle if it looks like more than three follicles have the potential to ovulate. This measure is taken to prevent the incidence of high order multiples.

Looking for more information on how Clomid can help you produce more eggs? Check out this video where Dr. Eric Flisser of the Reproductive Medicine Associates of New York explains how the drug can help:

Click image to play.

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