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Donor Egg IVF and PGS for Diminished Ovarian

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With age comes wisdom and experience. Unfortunately for women, age also brings diminished ovarian reserve- reduced quality and quantity of eggs in their ovaries. If a woman is not able to conceive with her own eggs, use of donor oocytes (eggs) with IVF, may be recommended. “Oocyte donation offers women in menopause, women with premature ovarian failure and women with diminished ovarian reserve the opportunity to not only become parents but also to carry a pregnancy,” says Dr. Jaime Knopman of RMA New York.

Until recently fertility doctors would transfer two or three embryos (created with the donor eggs and sperm) to a woman’s uterus during a donor egg IVF cycle. Although success rates were high, this protocol often resulted in pregnancy with high order multiples (twins, triplets) and increased health risks to the mother and babies. "Multiple gestations are at increased risk for preterm labor/preterm delivery (NICU admissions), neonatal morbidity/mortality, gestational diabetes, hypertensive disorders of pregnancy, cesarean delivery, anemia, hemorrhage, and post-partum depression," Knopman explains.

Today, doctors are utilizing techniques like Preimplantation Genetic Screening (PGS) with donor egg IVF cycles to select the single, healthiest embryo for transfer for a safer experience overall.

To learn more about egg donation and PGS, check out Dr. Knopman’s blog on

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