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Fertility of Women Who Survive Childhood Cancer: Results from the Childhood Cancer Survivor Study

by Daniel M. Green, MD,  American Journal of Hematology/Oncology,  Oct 12, 2009

In this article, the author offers a concise, practical summary of the research findings reported in Green DM, Kawashima T, Stovall M, et al. Fertility of female survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. J Clin Oncol. 2009;27(16):2677-2685.

Key research findings
● Female survivors from the Childhood Cancer Survivor Study cohort were less likely to become pregnant than their siblings

● A hypothalamic or pituitary radiation dose > 30 Gy or an ovarian/uterine radiation dose > 5 Gy was a significant risk factor among female survivors for not having a pregnancy

● Exposure to an alkylating chemotherapy agent was independently associated with reduced pregnancy risk in a dose-dependent manner
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