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Scientists Find Genetic Cause of Male Infertility

Time Online U.K.,  Sept 3, 2009
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Men who make no sperm at all and women with a sterilising disorder may both owe their infertility to the same surprising origin: a weakness in the Y chromosome that makes men male.

Scientists have discovered that a genetic proof-reading process that normally protects the Y chromosome against harmful mutations can itself inflict damage, triggering a wide range of sexual disorders that affect both genders.

This vulnerability appears to underlie many cases of male infertility, in which a man lacks genes on the Y chromosome that are essential to sperm production, but it can also cause intersex conditions and even a sex development disorder that only affects females. Read more.


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