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Comprehensive Chromosome Screen Shows Increased IVF Success

ASRM,  Oct 22, 2012

October 22, 2012

Researchers at the 2012 American Society for Reproductive Medicine Annual Meeting presented evidence that suggests a comprehensive chromosome screening of embryos could yield a greater number of successful pregnancies than traditional screening.

In a collaborative effort, researchers at the Colorado Center for Reproductive Medicine(CCRM) and Reproductive Medicine Associates of New Jersey (RMANJ) teamed up to test a new technique for screening out chromosomal abnormalities in embryos. Because these abnormalities account for nearly 70% of pregnancy loss in the first trimester, it is important to perfect methods for selecting genetically normal embryos to maximize chances for success in an in vitro fertilization (IVF) cycle.

Comprehensive Chromosomal Screening (CCS) allows embryologists to biopsy the top layer of cells in a 100+ cell blastocyst. All of the embryos tested with CCS were then frozen, and the ones found to be chromosomally healthy were thawed and transferred via IVF.

The group of patients who used CCS showed significantly increased success versus the patients who used traditional screening. This is an especially valuable tool for patients with advanced maternal age, as retrieving eggs with chromosomal abnormalities are far more likely.

Further research is warranted on a larger scale, and birth outcome data is needed to determine the success of CCS conclusively.

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