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Genetic Deletion Responsible for Male Infertility
October 29, 2012
The study is a first of its kind and used data obtained from over 20,000 screenings of men in five countries including the United States. The research team found two genetic deletions responsible for a combined 8% of severely low sperm count. To date, six deletions in the area of the Y chromosome have been reported, but the prevalence of these deletions in the general population and their risk for infertility were not quite understood.
The most common genetic deletion, gr/gr, was found in 2% of men as well as 2% of cases and almost doubled the risk of SSF. The b2/b4 deletion, while found in less than 1% of men, accounted for about 6% of cases and increased risk 145 times.
Though further research is needed, these findings indicate there is a lot to be learned of genetics and male infertility.
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