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Study Finds Treatment for Endometriosis; OHSS

FertilityAuthority,  April 5, 2013

April 5, 2013

The process of angiogenesis involves formation of new blood vessels throughout the body, including the uterus. In fact, it is a normal part of the menstrual cycle where blood vessels grow and break. Abnormal growth of these blood vessels, however, can be painful as is the case with endometriosis or ovarian hyperstimulation syndrome (OHSS). There are currently no treatments available for endometriosis or OHSS (other than to drain fluid in the instance of severe OHSS).

A new study out of Tel Aviv University, published in the Journal of Clinical Endocrinology and Metabolism, Human Reproduction, and Molecular Human Reproduction , has discovered a treatment that could address abnormal blood vessel growth. An injection of pigment epithelium derived factor (PEDF) protein can reverse the symptoms of conditions like endometriosis without risking the patient’s fertility.

In mouse studies, the effects of either condition were reversed. Abdominal swelling and lesions were diminished. Scientists also confirmed that PEDF had no negative effects on fertility, rather it boosted the number of eggs ovulated in an endometriosis model.

This therapy could drastically improve the lives of women with endometriosis who suffer severe pain, bleeding, and often infertility. Endometriosis is linked to lower egg quality while OHSS severe OHSS can result in fluid in the lungs and abdomen, trouble breathing, and risk of miscarriage.


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