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How Your AMH Level Can Predict Pregnancy Success

FertilityAuthority,  Feb 13, 2013

February 13, 2013

A study out of Sweden says Anti-Mullerian Hormone (AMH) can predict in vitro fertilization (IVF) success. In a sense, the data confirms what we’ve already known: higher levels of AMH means better ovarian reserve (quality and quantity). A fertility patient with a higher level of AMH will respond better to ovarian stimulation in an IVF cycle.

Accepted for publication in the Journal of Clinical Endocrinology & Metabolism, the study found that women with high AMH were 2.5 times more likely to get pregnant from an IVF cycle than women of the same age with low AMH. This study is the first of its kind to directly like AMH to successful pregnancy and live birth rates, as most studies have focused on AMH as a predictor of ovarian reserve.

Scientists examined data of 892 fertility patients who underwent more than 1,200 in vitro fertilization (IVF) cycles at the Carl von Linné Clinic in Uppsala, Sweden, between 2008 and 2011. Blood AMH levels were measured as part of a fertility workup prior to beginning treatment. The results indicated that women with higher AMH levels (above 2.94 ng/ml) had the highest live birth rates. Those with AMH levels below 0.2ng/ml experienced a much poorer response to stimulation. Only 18 embryo transfers took place in this group and only 3 children were born to the low AMH group.

This study unexpectedly produced data in support of IVF success for women with polycystic ovarian syndrome (PCOS), a fertility condition characterized in part by a high number of ovarian follicles, thus high AMH. IVF provides greater control over the cycle than intrauterine insemination (IUI), reduces the risk of cancelling a cycle due to overstimulation, and yields higher success rates with fewer physical and financial costs than IUI for this population.


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