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Genetic Testing with NGS

The latest iteration of comprehensive chromosomal screening (CCS) is called “next generation sequencing” (NGS). A recent study set out to clinically validate the technology; in a blinded, non-selection study, embryos were transferred without knowledge of NGS results to determine the predictive value (proportion of results that are true positive and true negative).

IVF with Next Generation Sequencing

A recent study compared the efficacy of two types of preimplantation genetic screening (PGS) used with IVF and single embryo transfer: next generation sequencing (NGS), and array Comparative Genomic Hybridization (aCGH). The researchers determined that clinical and ongoing pregnancy rates are comparable.

The Impact of PGS 40K cycle study demonstrates reduction of time to achieve pregnancy

Dr. Alan Copperman from RMA of New York discusses the impact that PGS has when used in fertility treatments. It has been found that if PGS is used it the time to a successful pregnancy is reduced.

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The Impact of Comprehensive Chromosomal Screening on IVF Embryo Selection

A recent study looked at embryo selection in an IVF cycle based on two different criteria: embryo morphology and chromosomal makeup. Researchers looked at day 5 embryos (blastocysts) that were graded using standard morphology, then tested with comprehensive chromosomal screening (CCS). The study concluded that when embryos are selected to transfer based solely on morphology, in 41% of cases the embryos chosen will be aneuploid (abnormal).

Why and How is PGS Useful?

Dr. Bruce Albrecht from Albrecht Women's Care talks about PGS. He talks about the advantages that PGS has including, a decreased amount of time that it takes to get pregnant as well as reducing the rate of miscarriages due to since the genetically abnormal embryos are not implanted.

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What Are the Advances in Genetic Testing with PGS?

Dr. John Norian of HRC Fertility discusses the recent advances that have taken place with PGS, genetic testing. The ability to examine an embryo further and to identify any abnormalities is an enormous advance in fertility treatment.

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