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Top 5 PCOS Questions and Answers: Metformin

Previous: What does insulin have to do with PCOS and why is my doctor talking to me about diabetes?

Q: What is Metformin and should I be taking it?

A: Metformin (also called glucophage) is a medication that helps control blood sugar levels. It is a common treatment for Type II Diabetes. Since women with PCOS may have early features of diabetes even before they fully develop Type II Diabetes, many women with PCOS are good candidates for Metformin use. If you have PCOS, your doctor will likely want to check your insulin and blood sugar levels. They will sometimes ask you to do a test called an Oral Glucose Tolerance Test. With this test, you have your blood checked in a fasting state and then you drink a cola with a high sugar content. Blood tests are checked one or two hours later to see how your body responded to the high sugar load. Based on your results, your doctor will let you know if Metformin is recommended or not.

Some women may begin to have more regular cycles once they start taking Metformin. If this is the case for you and you are trying to conceive, you may want to talk with your doctor about starting Clomid or Femara (letrozole) as you continue to take the Metformin. A great study was published by Dr. Richard Legro and several other authors that compared taking Metformin alone versus taking Clomid alone versus taking a combination of Metformin plus Clomid. Pregnancy rates were significantly higher in the groups taking Clomid and the combination of Metformin and Clomid over women simply taking Metformin alone.

Next: If I have PCOS and I am doing IVF, are there aspects of my IVF cycle that will be different due to my diagnosis of PCOS?

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Comments (2)

My overly size was increase.i had irregularity in periods doctor said your Harmon's are increased by 16.00 then she put me on metformin after taking that I have continuous bleeding sine 29june to 22 July I'm still bleeding after that she put me on another tablet but no use and now she pu Again put me on duphaston and it's my third day I'm taking tit but no use,,,,,,,,,,,,please some one is thee to tell me what's going on with me...I took metformin about 16 days

Hello Faadiaiqbahl - I'm so sorry to hear that you're having concerns. Have you discussed this with the doctor that prescribed you the Metformin and Duphaston? Have you considered getting a second opinion from a different doctor who may provide a different perspective? Have you consulted with a fertility specialist? If you live in the United States I'm more than happy to help you find a fertility specialist in your area. Feel free to email me directly at

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