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Novarel, Pregnyl, Profasl

Human Chorionic Gonadotropin (hCG), is sold under the brand names Novarel, Pregnyl and Profasi. It is a natural hormone produced by pregnant women in the placenta and extracted from the urine. hCG is typically used to trigger ovulation in a cycle where gonadotropins or hMG is used to induce ovulation – it’s often referred to as the trigger shot.

How it Works

Similar in chemical structure and function to LH, hCG helps with the final maturation of the eggs and triggers ovulation. In addition, HCG stimulates your corpus luteum to secrete progesterone and prepare the lining of your uterus for implantation of the fertilized egg. The hCG injection is usually only once in a cycle, and the timing will be based on factors including blood work and ultrasound. Ovulation usually occurs about 36 hours after hCG is administered.


Most patients only need one hCG injection, which may require upwards of six ampules of the medication.


Each ampules of hCG can cost between $35 and $75 each. The number of ampules needed may differ by patient and by cycle.


Comments (1)


I live in France and my doctor has prescribed HCG (Endo 5000 U.I./1ml), administered by intramuscular injection on days 20, 23 and 26 of my cycle. I also took Pergotime (50 mg Clomifene citrate) for the first five days of my cycle. He's not the most loquacious of doctors, so he didn't explain anything at all about the meds, or what I'm supposed to do in terms of best days to ttc. I'm hoping you can explain to me why I'm taking HCG so late in my cycle, as from everything I've read online, it's normally used to trigger ovulation. I was not told that I had any ovulation problems - the only problem he said I had was that the cervical mucus was a little thick. I can't understand why I would be taking HCG so late in my cycle, as I had thought that ovulation normally occurs mid-cycle.



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