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What Fertility Drugs are used with IUI?

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Intrauterine insemination (IUI) can be performed naturally: Sperm is prepared and delivered directly into a woman’s uterus when she is ovulating. However, IUI is often done in conjunction with fertility drugs such as Clomid to stimulate her body to develop multiple eggs. This process goes by many names, including superovulation, controlled ovarian hyperstimulation, and ovulation induction by hormone therapy.

Several studies have found that, for couples with unexplained infertility, IUI done along with superovulation offers a greater chance of pregnancy than IUI done in “natural” menstrual cycles. For couples with unexplained infertility, without superovulation, IUI produces similar pregnancy rates as well-timed intercourse.

One study, conducted by researchers at the University of Rochester Medical Center in the late 1990s, found that superovulation combined with IUI was associated with a three-fold higher chance of pregnancy than no treatment at all and a two-fold higher chance of pregnancy than either IUI or superovulation alone. Couples facing infertility who used both superovulation and IUI had a 33 percent pregnancy rate, compared with infertile couples who used no fertility treatments, who had a 10 percent pregnancy rate.

The Fertility Drug Options

The fertility drugs given during an IUI cycle include clomiphene citrate (such as Clomid), aromatase inhibitors (such as letrozole), and gonadotropins (such as hMG). Studies have found that clomiphene citrate and letrozole have comparable pregnancy rates. Insemination with gonadotropins, however, provides better pregnancy rates (around 15 percent per cycle for couples with unexplained infertility) than insemination with clomiphene (around 5 to 10 percent per cycle). That’s because gonadotropins usually stimulate more mature eggs to develop.

Women usually begin taking these fertility drugs early in the menstrual cycle, on the second, third, fourth, or fifth day after they get their periods.

Soon after that, a woman’s doctor will begin watching for signs of ovulation to know when to schedule the IUI. However, sometimes when women are given these medications to stimulate ovulation, it can prevent the natural LH surge that triggers ovulation from occurring. If this is the case, the woman will receive (or give herself) an injection of human chorionic gonadrotropin (hCG) in the evening. That shot will trigger ovulation within 36 to 40 hours. The IUI is usually scheduled around 36 hours after the shot.

Risks of Fertility Drugs and IUI

All ovulation medications have the increased risk of multiples: twins, triplets and more. However, studies have found that in women with infertility caused by mild endometriosis, the combination of IUI and superovulation with gonadotropins had a much higher birth rate than in women who received no fertility treatment.

Although there have been concerns of these fertility drugscausing birth defects, according to the American Society for Reproductive Medicine (ASRM), “clomiphene citrate and gonadotropins are not associated with an increased risk of birth defects.” However, there is concern that letrozole may be associated with an increased risk of birth defects.

Also, many fear a connection between these fertility drugs and an increased risk of cancer in women. Recent studies have not found a link between superovulation and ovarian cancer. However, in 2006, researchers in Israel found that women taking clomiphene citrate had an elevated risk of breast cancer.

For more information on fertility drugs and IUI, read:


Comments (9)

Hi Nathan,

Cysts are fluid filled follicles. There are two possible scenarios: The follicle that was stimulated by the Clomid released an egg, then sealed itself again causing a cyst, or the follicle never released an egg and lingered around as a cyst. The latter is common with PCOS. What is your wife's diagnosis?


Hi every body, i got pregnant via iui. now im 6 months pg. i used some fertility drugs like letroz2.5, gmh 75 inj, hucog 5000 inj. some of my friends telling that these medicines leads to abnormalities in baby. please tell me is that true.

How will taking amoxicillin for a possible Lyme infected tick effect the prepartion for IUI and the chances of success?

I'm 38, I've been trying to get pregnant for the past 5 years, and I've tried every fertility treatment out there so far. IUI done along with superovulation could be the solution for me. My husband wanted to buy legal steroids and take them because he heard they might improve fertility, but I strongly opposed it, because I want my child to be healthy.

A fertility workup performed by a fertility specialist (reproductive endocrinologist) will help diagnose the cause of your infertility, and from there a treatment plan will be determined.

How do you choose the right procedure?

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